The chronicity of tonsillitis is significantly correlated with an increase in an LTi cell portion

Jung Hyun Chang, Soochan Kim, Jihye Koo, Peter J.L. Lane, Sun Och Yoon, Ah Young Park, Kyung Su Kim, Mi Yeon Kim

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The current study explored the relationship between lymphoid tissue inducer (LTi) cells and patients' clinical and immunological status. LTi cells are critical for lymphoid tissue development and maintenance of CD4 T cell-dependent immune responses. The percentage of CD117+CD3-CD56 -CD127+ RORγ+ LTi cells isolated from human tonsils was determined and correlated with changes in other immune subsets and clinical factors. We found that the portion of LTi and CD4 T cells was significantly increased in chronic tonsillitis compared to non-inflamed tonsils. Additionally, the expression of OX40 by memory CD4 T cells and OX40 ligand (OX40L) and interleukin (IL)-22 by LTi cells was higher in chronically inflamed tonsils. The treatment for tonsillitis with ibuprofen did not alter LTi cell viability and the expression of OX40L and IL-22. These results demonstrate that during chronic inflammation, LTi cells are increased and express higher levels of OX40L and IL-22, and this is correlated with an increase in memory CD4 T cells.

Original languageEnglish
Pages (from-to)132-141
Number of pages10
Issue number1
Publication statusPublished - 2014 Feb

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2011–0024205).

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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