The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo

Juyeon Jung, Yeon Sung Son, Hongryeol Park, Seong Kook Jeon, Jung Whoi Lee, Song Yi Choi, Jin Man Kim, Young Guen Kwon, Hyo Jeong Hong, Jeong Ki Min

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Recent studies have demonstrated that the cell adhesion molecule, L1, is expressed in several malignant tumor types and its expression correlates with tumor progression and metastasis. However, the role of L1 in gallbladder carcinoma (GBC) remains unclear. Here, we demonstrate that L1 is expressed in GBC cells and plays an important role in the growth, motility, invasiveness, and adhesiveness of GBC cells. Specific depletion or overexpression of L1 in the GBC cell lines JCRB1033 and SNU-308, respectively, was achieved by lentivirus-mediated transduction and expression of an L1 mRNA-specific short hairpin RNA or full-length human L1. Stable depletion of L1 led to a significant decrease in GBC cell proliferation, migration and invasion, as well as decreased intracellular signaling through AKT and FAK. Overexpression of L1 in GBC cells enhanced these cellular activities. In a GBC xenograft nude mouse model, suppression of L1 markedly reduced tumor growth and increased the survival of tumor-bearing mice whereas L1 overexpression stimulated tumorigenicity. Taken together, these results suggest that L1 plays a crucial role in GBC progression and may be a novel therapeutic target in GBC treatment.

Original languageEnglish
Pages (from-to)945-952
Number of pages8
JournalOncology reports
Issue number4
Publication statusPublished - 2011 Apr

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


Dive into the research topics of 'The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo'. Together they form a unique fingerprint.

Cite this