The cDNA cloning and ontogeny of mouse α-synuclein

Lyhna Hong, Hyuk Wan Ko, B. J. Gwag, Eunhye Joe, Seoungoh Lee, Young Tae Kim, Yoo Hun Suh

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


ALPHA-SYNUCLEIN has been implicated in the pathogenesis of Parkinson's disease. To investigate the role of α-synuclein in the brain, the cDNA clone encoding the mouse cognate of the human α-synuclein was isolated from a mouse brain cDNA library. The open reading frame coded for 140 amino acids that share 95% identity with human α-synuclein. Northern blot analysis showed that α-synuclein mRNA was primarily expressed in brain and spleen of adult mouse. In situ hybridization histochemistry revealed the highest expression of α-synuclein mRNA in the hippocampal formation and neocortex of the adult mouse. α-Synuclein mRNA expression in the brain was first observed in the hippocampus and neocortex on postnatal day 1. Levels of α-synuclein mRNA in these forebrain areas were nearly maximal at postnatal day 7 and remained relatively high until the adult stage. α-Synuclein mRNA was expressed in the liver transiently during embryogenesis.

Original languageEnglish
Pages (from-to)1239-1243
Number of pages5
Issue number6
Publication statusPublished - 1998 Apr 20

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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