The biomimetic apatite-cefalotin coatings on modifed titanium

Min Kyung Kang, Sang Bae Lee, Seung Kyun Moon, Kwang Mahn Kim, Kyoung Nam Kim

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Dental implant failure often occurs due to oral bacterial infection. The aim of this study was to demonstrate that antibiotic effcacy could be enhanced with modifed titanium. First, the titanium was modifed by anodization and heat-treatment. Then, a biomimetic coating process was completed in two steps. Surface characterization was performed with scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction. Release of antibiotic was evaluated by UV/VIS spectrometry, and the antibacterial effect was evaluated on Streptococcus mutans. After the second coating step, we observed a thick homogeneous apatite layer that contained the antibiotic, cefalotin. The titanium formed a rutile phase after the heat treatment, and a carbonated apatite phase appeared after biomimetic coating. We found that the modifed titanium increased the loading of cefalotin onto the hydroxyapatite coated surface. The results suggested that modifed titanium coated with a cefalotin using biomimetic coating method might be useful for preventing local post-surgical implant infections.

Original languageEnglish
Pages (from-to)98-105
Number of pages8
JournalDental Materials Journal
Issue number1
Publication statusPublished - 2012 Jan 21

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • General Dentistry


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