TY - JOUR
T1 - The association of total and differential white blood cell count with metabolic syndrome in type 2 diabetic patients
AU - Shim, Wan Sub
AU - Kim, Hae Jin
AU - Kang, Eun Seok
AU - Ahn, Chul Woo
AU - Lim, Sung Kil
AU - Lee, Hyun Chul
AU - Cha, Bong Soo
PY - 2006/9
Y1 - 2006/9
N2 - Aims: We investigated the relation between total and differential white blood cell (WBC) count and metabolic syndrome (MS) in type 2 diabetic patients. Methods: Eight-hundred and twenty-two patients (males 430, females 392, BMI 25.4 ± 3.2 kg/m2, duration of diabetes 5.7 ± 6.8 years) were enrolled in this study. We measured total WBC count and differential count, anthropometry, blood pressure, fasting glucose, insulin and lipid profiles. Results: The number of components of MS and prevalence of MS were increased from 1st quartile to 4th quartile of WBC count. Total WBC, neutrophil, lymphocyte, monocyte and eosinophil counts were increased with the increase of number of components of MS except basophil count. Total WBC, neutrophil, lymphocyte, monocyte and eosinophil counts were higher in the patients with MS features than those without MS features. WBC count was positively correlated with waist circumference (γ = 0.134), systolic blood pressure (γ = 0.082), diastolic blood pressure (γ = 0.083), triglyceride (γ = 0.241), insulin (γ = 0.222), and HOMA-IR (γ = 0.225), and negatively with HDL cholesterol (γ = -0.146) (p < 0.05, respectively). Conclusions: Chronic inflammation, as indicated by a higher WBC count, may be related with the increased number of components of MS in type 2 diabetic patients.
AB - Aims: We investigated the relation between total and differential white blood cell (WBC) count and metabolic syndrome (MS) in type 2 diabetic patients. Methods: Eight-hundred and twenty-two patients (males 430, females 392, BMI 25.4 ± 3.2 kg/m2, duration of diabetes 5.7 ± 6.8 years) were enrolled in this study. We measured total WBC count and differential count, anthropometry, blood pressure, fasting glucose, insulin and lipid profiles. Results: The number of components of MS and prevalence of MS were increased from 1st quartile to 4th quartile of WBC count. Total WBC, neutrophil, lymphocyte, monocyte and eosinophil counts were increased with the increase of number of components of MS except basophil count. Total WBC, neutrophil, lymphocyte, monocyte and eosinophil counts were higher in the patients with MS features than those without MS features. WBC count was positively correlated with waist circumference (γ = 0.134), systolic blood pressure (γ = 0.082), diastolic blood pressure (γ = 0.083), triglyceride (γ = 0.241), insulin (γ = 0.222), and HOMA-IR (γ = 0.225), and negatively with HDL cholesterol (γ = -0.146) (p < 0.05, respectively). Conclusions: Chronic inflammation, as indicated by a higher WBC count, may be related with the increased number of components of MS in type 2 diabetic patients.
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U2 - 10.1016/j.diabres.2006.02.001
DO - 10.1016/j.diabres.2006.02.001
M3 - Article
C2 - 16563549
AN - SCOPUS:33746273256
SN - 0168-8227
VL - 73
SP - 284
EP - 291
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 3
ER -
