The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss

M. J. Shin; Y. Jang; S. J. Koh; J. S. Chae; O. Y. Kim; J. E. Lee; J. M. Ordovas; J. H. Lee

doi:10.1038/sj.ijo.0803338

The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss

M. J. Shin, Y. Jang, S. J. Koh, J. S. Chae, O. Y. Kim, J. E. Lee, J. M. Ordovas, J. H. Lee

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective:The purpose of this study was to determine whether common single nucleotide polymorphisms (SNPs) at the adiponectin (ADIPOQ) locus influence changes in circulating adiponectin and the features of insulin resistance in response to a weight loss intervention.Subjects:In total, 294 nondiabetic/overweight-obese Koreans participated in a clinical intervention study lasting 12 weeks involving a caloric reduction of -300kcal/day.Methods: Plasma adiponectin, blood lipids, glucose and insulin concentrations were measured at baseline and after weight loss. Insulin resistance was estimated by homeostasis model assessment insulin resistance (HOMA-IR) derived from fasting glucose and insulin concentrations. We genotyped for three SNPs, 45T>G, 276G>T and -11377C>G.Results:At baseline, HOMA-IR was significantly higher in GG homozygotes than in carriers of the T allele at SNP276G>T of the adiponectin gene (P<0.05). With regard to SNP45T>G and SNP -11377C>G, we did not find any genotype related differences in baseline levels of HOMA-IR and adiponectin. In the 45/276 haplotype test, homozygous for the TG haplotype had significantly lower concentrations of plasma adiponectin (P<0.05). After the 12-week weight loss intervention, the significant decreases in HOMA-IR (P<0.001) and increases in adiponectin (P<0.01) were observed in GG homozygotes at SNP276, which were not shown in carriers of the T allele. Furthermore, there was a significant difference in the decreases in HOMA-IR between the GG homozygotes and carriers of the T allele at SNP276 (P<0.05). Regarding SNP45T>G and SNP -11377C>G, there was no association between SNP45T>G and SNP -11377C>G and decreases in HOMA-IR. In the 45/276 haplotype test, there was a significant difference in changes of adiponectin levels among those with different haplotype combinations (P<0.05).Conclusion: The SNP276G>T of the ADIPOQ gene is associated with different responses of circulating adiponectin and insulin resistance to mild weight loss in overweight-obese subjects.

Original language	English
Pages (from-to)	1702-1708
Number of pages	7
Journal	International Journal of Obesity
Volume	30
Issue number	12
DOIs	https://doi.org/10.1038/sj.ijo.0803338
Publication status	Published - 2006 Dec 21

Bibliographical note

Funding Information:
We thank Patty W Siri of Children’s Hospital Oakland Research Institute (CHORI) for her expert help. Financial support: (1) National Research Laboratory project, Ministry of Science & Technology (2005-01572) (2) Korea Science and Engineering Foundation (R01-2003-0000-11709-0) (3) Korea Health 21 R&D Projects, Ministry of Health & Welfare (00-PJ3-PG6-GN-01-0001), Republic of Korea (4) NIH/NHLBI # HL54776, and contracts 53-K06-5-10 and 58-1950-9-001 from the US Department of Agriculture Research Service (5) Korea Health 21 R&D Projects, Ministry of Health & Welfare, Republic of Korea (02-PJ1-PG1-CH15-0001).

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

UN SDGs

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10.1038/sj.ijo.0803338

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@article{d536f470eaae4859b00ed44abaefd181,

title = "The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss",

abstract = "Objective:The purpose of this study was to determine whether common single nucleotide polymorphisms (SNPs) at the adiponectin (ADIPOQ) locus influence changes in circulating adiponectin and the features of insulin resistance in response to a weight loss intervention.Subjects:In total, 294 nondiabetic/overweight-obese Koreans participated in a clinical intervention study lasting 12 weeks involving a caloric reduction of -300kcal/day.Methods: Plasma adiponectin, blood lipids, glucose and insulin concentrations were measured at baseline and after weight loss. Insulin resistance was estimated by homeostasis model assessment insulin resistance (HOMA-IR) derived from fasting glucose and insulin concentrations. We genotyped for three SNPs, 45T>G, 276G>T and -11377C>G.Results:At baseline, HOMA-IR was significantly higher in GG homozygotes than in carriers of the T allele at SNP276G>T of the adiponectin gene (P<0.05). With regard to SNP45T>G and SNP -11377C>G, we did not find any genotype related differences in baseline levels of HOMA-IR and adiponectin. In the 45/276 haplotype test, homozygous for the TG haplotype had significantly lower concentrations of plasma adiponectin (P<0.05). After the 12-week weight loss intervention, the significant decreases in HOMA-IR (P<0.001) and increases in adiponectin (P<0.01) were observed in GG homozygotes at SNP276, which were not shown in carriers of the T allele. Furthermore, there was a significant difference in the decreases in HOMA-IR between the GG homozygotes and carriers of the T allele at SNP276 (P<0.05). Regarding SNP45T>G and SNP -11377C>G, there was no association between SNP45T>G and SNP -11377C>G and decreases in HOMA-IR. In the 45/276 haplotype test, there was a significant difference in changes of adiponectin levels among those with different haplotype combinations (P<0.05).Conclusion: The SNP276G>T of the ADIPOQ gene is associated with different responses of circulating adiponectin and insulin resistance to mild weight loss in overweight-obese subjects.",

author = "Shin, {M. J.} and Y. Jang and Koh, {S. J.} and Chae, {J. S.} and Kim, {O. Y.} and Lee, {J. E.} and Ordovas, {J. M.} and Lee, {J. H.}",

note = "Funding Information: We thank Patty W Siri of Children{\textquoteright}s Hospital Oakland Research Institute (CHORI) for her expert help. Financial support: (1) National Research Laboratory project, Ministry of Science & Technology (2005-01572) (2) Korea Science and Engineering Foundation (R01-2003-0000-11709-0) (3) Korea Health 21 R&D Projects, Ministry of Health & Welfare (00-PJ3-PG6-GN-01-0001), Republic of Korea (4) NIH/NHLBI # HL54776, and contracts 53-K06-5-10 and 58-1950-9-001 from the US Department of Agriculture Research Service (5) Korea Health 21 R&D Projects, Ministry of Health & Welfare, Republic of Korea (02-PJ1-PG1-CH15-0001).",

year = "2006",

month = dec,

day = "21",

doi = "10.1038/sj.ijo.0803338",

language = "English",

volume = "30",

pages = "1702--1708",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "Nature Publishing Group",

number = "12",

}

TY - JOUR

T1 - The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss

AU - Shin, M. J.

AU - Jang, Y.

AU - Koh, S. J.

AU - Chae, J. S.

AU - Kim, O. Y.

AU - Lee, J. E.

AU - Ordovas, J. M.

AU - Lee, J. H.

N1 - Funding Information: We thank Patty W Siri of Children’s Hospital Oakland Research Institute (CHORI) for her expert help. Financial support: (1) National Research Laboratory project, Ministry of Science & Technology (2005-01572) (2) Korea Science and Engineering Foundation (R01-2003-0000-11709-0) (3) Korea Health 21 R&D Projects, Ministry of Health & Welfare (00-PJ3-PG6-GN-01-0001), Republic of Korea (4) NIH/NHLBI # HL54776, and contracts 53-K06-5-10 and 58-1950-9-001 from the US Department of Agriculture Research Service (5) Korea Health 21 R&D Projects, Ministry of Health & Welfare, Republic of Korea (02-PJ1-PG1-CH15-0001).

PY - 2006/12/21

Y1 - 2006/12/21

N2 - Objective:The purpose of this study was to determine whether common single nucleotide polymorphisms (SNPs) at the adiponectin (ADIPOQ) locus influence changes in circulating adiponectin and the features of insulin resistance in response to a weight loss intervention.Subjects:In total, 294 nondiabetic/overweight-obese Koreans participated in a clinical intervention study lasting 12 weeks involving a caloric reduction of -300kcal/day.Methods: Plasma adiponectin, blood lipids, glucose and insulin concentrations were measured at baseline and after weight loss. Insulin resistance was estimated by homeostasis model assessment insulin resistance (HOMA-IR) derived from fasting glucose and insulin concentrations. We genotyped for three SNPs, 45T>G, 276G>T and -11377C>G.Results:At baseline, HOMA-IR was significantly higher in GG homozygotes than in carriers of the T allele at SNP276G>T of the adiponectin gene (P<0.05). With regard to SNP45T>G and SNP -11377C>G, we did not find any genotype related differences in baseline levels of HOMA-IR and adiponectin. In the 45/276 haplotype test, homozygous for the TG haplotype had significantly lower concentrations of plasma adiponectin (P<0.05). After the 12-week weight loss intervention, the significant decreases in HOMA-IR (P<0.001) and increases in adiponectin (P<0.01) were observed in GG homozygotes at SNP276, which were not shown in carriers of the T allele. Furthermore, there was a significant difference in the decreases in HOMA-IR between the GG homozygotes and carriers of the T allele at SNP276 (P<0.05). Regarding SNP45T>G and SNP -11377C>G, there was no association between SNP45T>G and SNP -11377C>G and decreases in HOMA-IR. In the 45/276 haplotype test, there was a significant difference in changes of adiponectin levels among those with different haplotype combinations (P<0.05).Conclusion: The SNP276G>T of the ADIPOQ gene is associated with different responses of circulating adiponectin and insulin resistance to mild weight loss in overweight-obese subjects.

AB - Objective:The purpose of this study was to determine whether common single nucleotide polymorphisms (SNPs) at the adiponectin (ADIPOQ) locus influence changes in circulating adiponectin and the features of insulin resistance in response to a weight loss intervention.Subjects:In total, 294 nondiabetic/overweight-obese Koreans participated in a clinical intervention study lasting 12 weeks involving a caloric reduction of -300kcal/day.Methods: Plasma adiponectin, blood lipids, glucose and insulin concentrations were measured at baseline and after weight loss. Insulin resistance was estimated by homeostasis model assessment insulin resistance (HOMA-IR) derived from fasting glucose and insulin concentrations. We genotyped for three SNPs, 45T>G, 276G>T and -11377C>G.Results:At baseline, HOMA-IR was significantly higher in GG homozygotes than in carriers of the T allele at SNP276G>T of the adiponectin gene (P<0.05). With regard to SNP45T>G and SNP -11377C>G, we did not find any genotype related differences in baseline levels of HOMA-IR and adiponectin. In the 45/276 haplotype test, homozygous for the TG haplotype had significantly lower concentrations of plasma adiponectin (P<0.05). After the 12-week weight loss intervention, the significant decreases in HOMA-IR (P<0.001) and increases in adiponectin (P<0.01) were observed in GG homozygotes at SNP276, which were not shown in carriers of the T allele. Furthermore, there was a significant difference in the decreases in HOMA-IR between the GG homozygotes and carriers of the T allele at SNP276 (P<0.05). Regarding SNP45T>G and SNP -11377C>G, there was no association between SNP45T>G and SNP -11377C>G and decreases in HOMA-IR. In the 45/276 haplotype test, there was a significant difference in changes of adiponectin levels among those with different haplotype combinations (P<0.05).Conclusion: The SNP276G>T of the ADIPOQ gene is associated with different responses of circulating adiponectin and insulin resistance to mild weight loss in overweight-obese subjects.

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The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss

Abstract

Bibliographical note

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