The association between low blood lead levels and the prevalence of prehypertension among nonhypertensive adults in Korea

Wanhyung Lee; Jin Ha Yoon; Jaehoon Roh; Seunghyun Lee; Hongdeok Seok; June Hee Lee; Pil Kyun Jung; Jeongbae Rhie; Jong Uk Won

doi:10.1002/ajhb.22857

The association between low blood lead levels and the prevalence of prehypertension among nonhypertensive adults in Korea

Wanhyung Lee, Jin Ha Yoon, Jaehoon Roh, Seunghyun Lee, Hongdeok Seok, June Hee Lee, Pil Kyun Jung, Jeongbae Rhie, Jong Uk Won

Department of Preventive Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

OBJECTIVES: Low-level lead exposure has been associated with increases in blood pressure (BP) and impairment of the cardiovascular system. Prehypertension is not categorized as a disease currently; however, individuals with untreated prehypertension are known to be at increased risk of progression to hypertension and mortality caused by cardiovascular disease. We investigated the association between blood lead levels below the threshold for the harmful effects of lead and the prevalence of prehypertension in Korean adults.

METHODS: A total of 8,493 participants (3,945 men and 4,548 women) were included in the current analysis, using data from the fourth, fifth, and sixth Korean National Health and Nutrition Examination Survey (KNHANES) in 2007-2013. Blood analysis, self-report questionnaires, and physical examinations were used to assess blood lead levels, BP, and medical history. Odds ratios (OR) and 95% confidence intervals (95% CI) for prehypertension were calculated using multiple logistic regression models.

RESULTS: Compared to the first quartile (Q1) blood lead level (0.206-1.539 μg/dl), the ORs (95% CI) were 1.24 (1.04-1.48) in Q2, (1.540-2.056 μg/dl), 1.27 (1.06-1.52) in Q3, (2.057-2.716 μg/dl), and 1.30 (1.07-1.60) in Q4 (2.717-24.532 μg/dl) for the prevalence of prehypertension after adjusting for age, sex, morbidity status, socioeconomic status, and health behavioral variables.

CONCLUSIONS: Our large, cross-sectional, nationwide study revealed that blood lead levels below the threshold for the harmful effects of lead were significantly associated with prehypertension. Am. J. Hum. Biol. 28:729-735, 2016.

Original language	English
Pages (from-to)	729-735
Number of pages	7
Journal	American journal of human biology : the official journal of the Human Biology Council
Volume	28
Issue number	5
DOIs	https://doi.org/10.1002/ajhb.22857
Publication status	Published - 2016 Sept 10

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Publisher Copyright:
© 2016 Wiley Periodicals, Inc.

All Science Journal Classification (ASJC) codes

Anatomy
Ecology, Evolution, Behavior and Systematics
Anthropology
Genetics

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajhb.22857

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@article{f42ceef9882544b5a92b34a9e74e9ae6,

title = "The association between low blood lead levels and the prevalence of prehypertension among nonhypertensive adults in Korea",

abstract = "OBJECTIVES: Low-level lead exposure has been associated with increases in blood pressure (BP) and impairment of the cardiovascular system. Prehypertension is not categorized as a disease currently; however, individuals with untreated prehypertension are known to be at increased risk of progression to hypertension and mortality caused by cardiovascular disease. We investigated the association between blood lead levels below the threshold for the harmful effects of lead and the prevalence of prehypertension in Korean adults.METHODS: A total of 8,493 participants (3,945 men and 4,548 women) were included in the current analysis, using data from the fourth, fifth, and sixth Korean National Health and Nutrition Examination Survey (KNHANES) in 2007-2013. Blood analysis, self-report questionnaires, and physical examinations were used to assess blood lead levels, BP, and medical history. Odds ratios (OR) and 95% confidence intervals (95% CI) for prehypertension were calculated using multiple logistic regression models.RESULTS: Compared to the first quartile (Q1) blood lead level (0.206-1.539 μg/dl), the ORs (95% CI) were 1.24 (1.04-1.48) in Q2, (1.540-2.056 μg/dl), 1.27 (1.06-1.52) in Q3, (2.057-2.716 μg/dl), and 1.30 (1.07-1.60) in Q4 (2.717-24.532 μg/dl) for the prevalence of prehypertension after adjusting for age, sex, morbidity status, socioeconomic status, and health behavioral variables.CONCLUSIONS: Our large, cross-sectional, nationwide study revealed that blood lead levels below the threshold for the harmful effects of lead were significantly associated with prehypertension. Am. J. Hum. Biol. 28:729-735, 2016.",

author = "Wanhyung Lee and Yoon, {Jin Ha} and Jaehoon Roh and Seunghyun Lee and Hongdeok Seok and Lee, {June Hee} and Jung, {Pil Kyun} and Jeongbae Rhie and Won, {Jong Uk}",

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year = "2016",

month = sep,

day = "10",

doi = "10.1002/ajhb.22857",

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The association between low blood lead levels and the prevalence of prehypertension among nonhypertensive adults in Korea. / Lee, Wanhyung; Yoon, Jin Ha; Roh, Jaehoon et al.
In: American journal of human biology : the official journal of the Human Biology Council, Vol. 28, No. 5, 10.09.2016, p. 729-735.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The association between low blood lead levels and the prevalence of prehypertension among nonhypertensive adults in Korea

AU - Lee, Wanhyung

AU - Yoon, Jin Ha

AU - Roh, Jaehoon

AU - Lee, Seunghyun

AU - Seok, Hongdeok

AU - Lee, June Hee

AU - Jung, Pil Kyun

AU - Rhie, Jeongbae

AU - Won, Jong Uk

PY - 2016/9/10

Y1 - 2016/9/10

N2 - OBJECTIVES: Low-level lead exposure has been associated with increases in blood pressure (BP) and impairment of the cardiovascular system. Prehypertension is not categorized as a disease currently; however, individuals with untreated prehypertension are known to be at increased risk of progression to hypertension and mortality caused by cardiovascular disease. We investigated the association between blood lead levels below the threshold for the harmful effects of lead and the prevalence of prehypertension in Korean adults.METHODS: A total of 8,493 participants (3,945 men and 4,548 women) were included in the current analysis, using data from the fourth, fifth, and sixth Korean National Health and Nutrition Examination Survey (KNHANES) in 2007-2013. Blood analysis, self-report questionnaires, and physical examinations were used to assess blood lead levels, BP, and medical history. Odds ratios (OR) and 95% confidence intervals (95% CI) for prehypertension were calculated using multiple logistic regression models.RESULTS: Compared to the first quartile (Q1) blood lead level (0.206-1.539 μg/dl), the ORs (95% CI) were 1.24 (1.04-1.48) in Q2, (1.540-2.056 μg/dl), 1.27 (1.06-1.52) in Q3, (2.057-2.716 μg/dl), and 1.30 (1.07-1.60) in Q4 (2.717-24.532 μg/dl) for the prevalence of prehypertension after adjusting for age, sex, morbidity status, socioeconomic status, and health behavioral variables.CONCLUSIONS: Our large, cross-sectional, nationwide study revealed that blood lead levels below the threshold for the harmful effects of lead were significantly associated with prehypertension. Am. J. Hum. Biol. 28:729-735, 2016.

AB - OBJECTIVES: Low-level lead exposure has been associated with increases in blood pressure (BP) and impairment of the cardiovascular system. Prehypertension is not categorized as a disease currently; however, individuals with untreated prehypertension are known to be at increased risk of progression to hypertension and mortality caused by cardiovascular disease. We investigated the association between blood lead levels below the threshold for the harmful effects of lead and the prevalence of prehypertension in Korean adults.METHODS: A total of 8,493 participants (3,945 men and 4,548 women) were included in the current analysis, using data from the fourth, fifth, and sixth Korean National Health and Nutrition Examination Survey (KNHANES) in 2007-2013. Blood analysis, self-report questionnaires, and physical examinations were used to assess blood lead levels, BP, and medical history. Odds ratios (OR) and 95% confidence intervals (95% CI) for prehypertension were calculated using multiple logistic regression models.RESULTS: Compared to the first quartile (Q1) blood lead level (0.206-1.539 μg/dl), the ORs (95% CI) were 1.24 (1.04-1.48) in Q2, (1.540-2.056 μg/dl), 1.27 (1.06-1.52) in Q3, (2.057-2.716 μg/dl), and 1.30 (1.07-1.60) in Q4 (2.717-24.532 μg/dl) for the prevalence of prehypertension after adjusting for age, sex, morbidity status, socioeconomic status, and health behavioral variables.CONCLUSIONS: Our large, cross-sectional, nationwide study revealed that blood lead levels below the threshold for the harmful effects of lead were significantly associated with prehypertension. Am. J. Hum. Biol. 28:729-735, 2016.

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The association between low blood lead levels and the prevalence of prehypertension among nonhypertensive adults in Korea

Abstract

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