Tetrasomy 8 in a patient with acute monoblastic Leukemia

Juwon Kim, Tae Sung Park, Jaewoo Song, Kyung A. Lee, Sang Guk Lee, June Won Cheong, Jong Rak Choi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Trisomy 8 is one of the most frequent numerical chromosomal abnormalities observed in hematological malignancies, whereas tetrasomy 8 is a clonal aberration seen mainly in myeloid disorders such as acute myelod leukemia (AML) and myelodysplastic syndromes. In contrast to trisomy 8, tetrasomy 8 is a rare chromosomal aberration, in that only 17 reported AML cases with isolated tetrasomy 8 have been documented. Interestingly, the majority of reported cases were associated with monocytic-lineage leukemias. According to recent reports, tetrasomy 8 is regarded as a poor prognostic factor, and most patients having this abnormality relapsed and died within 1 yr. Here, we report a patient with acute monoblastic leukemia having tetrasomy 8 and a very aggressive disease course.

Original languageEnglish
Pages (from-to)262-266
Number of pages5
JournalKorean Journal of Laboratory Medicine
Issue number4
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical


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