Tetrasomy 8 in a patient with acute monoblastic Leukemia

Juwon Kim; Tae Sung Park; Jaewoo Song; Kyung A. Lee; Sang Guk Lee; June Won Cheong; Jong Rak Choi

doi:10.3343/kjlm.2008.28.4.262

Tetrasomy 8 in a patient with acute monoblastic Leukemia

Juwon Kim, Tae Sung Park, Jaewoo Song, Kyung A. Lee, Sang Guk Lee, June Won Cheong, Jong Rak Choi

Department of Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Trisomy 8 is one of the most frequent numerical chromosomal abnormalities observed in hematological malignancies, whereas tetrasomy 8 is a clonal aberration seen mainly in myeloid disorders such as acute myelod leukemia (AML) and myelodysplastic syndromes. In contrast to trisomy 8, tetrasomy 8 is a rare chromosomal aberration, in that only 17 reported AML cases with isolated tetrasomy 8 have been documented. Interestingly, the majority of reported cases were associated with monocytic-lineage leukemias. According to recent reports, tetrasomy 8 is regarded as a poor prognostic factor, and most patients having this abnormality relapsed and died within 1 yr. Here, we report a patient with acute monoblastic leukemia having tetrasomy 8 and a very aggressive disease course.

Original language	English
Pages (from-to)	262-266
Number of pages	5
Journal	Korean Journal of Laboratory Medicine
Volume	28
Issue number	4
DOIs	https://doi.org/10.3343/kjlm.2008.28.4.262
Publication status	Published - 2008

All Science Journal Classification (ASJC) codes

Clinical Biochemistry
Biochemistry, medical

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10.3343/kjlm.2008.28.4.262

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title = "Tetrasomy 8 in a patient with acute monoblastic Leukemia",

abstract = "Trisomy 8 is one of the most frequent numerical chromosomal abnormalities observed in hematological malignancies, whereas tetrasomy 8 is a clonal aberration seen mainly in myeloid disorders such as acute myelod leukemia (AML) and myelodysplastic syndromes. In contrast to trisomy 8, tetrasomy 8 is a rare chromosomal aberration, in that only 17 reported AML cases with isolated tetrasomy 8 have been documented. Interestingly, the majority of reported cases were associated with monocytic-lineage leukemias. According to recent reports, tetrasomy 8 is regarded as a poor prognostic factor, and most patients having this abnormality relapsed and died within 1 yr. Here, we report a patient with acute monoblastic leukemia having tetrasomy 8 and a very aggressive disease course.",

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T1 - Tetrasomy 8 in a patient with acute monoblastic Leukemia

AU - Kim, Juwon

AU - Park, Tae Sung

AU - Song, Jaewoo

AU - Lee, Kyung A.

AU - Lee, Sang Guk

AU - Cheong, June Won

AU - Choi, Jong Rak

PY - 2008

Y1 - 2008

N2 - Trisomy 8 is one of the most frequent numerical chromosomal abnormalities observed in hematological malignancies, whereas tetrasomy 8 is a clonal aberration seen mainly in myeloid disorders such as acute myelod leukemia (AML) and myelodysplastic syndromes. In contrast to trisomy 8, tetrasomy 8 is a rare chromosomal aberration, in that only 17 reported AML cases with isolated tetrasomy 8 have been documented. Interestingly, the majority of reported cases were associated with monocytic-lineage leukemias. According to recent reports, tetrasomy 8 is regarded as a poor prognostic factor, and most patients having this abnormality relapsed and died within 1 yr. Here, we report a patient with acute monoblastic leukemia having tetrasomy 8 and a very aggressive disease course.

AB - Trisomy 8 is one of the most frequent numerical chromosomal abnormalities observed in hematological malignancies, whereas tetrasomy 8 is a clonal aberration seen mainly in myeloid disorders such as acute myelod leukemia (AML) and myelodysplastic syndromes. In contrast to trisomy 8, tetrasomy 8 is a rare chromosomal aberration, in that only 17 reported AML cases with isolated tetrasomy 8 have been documented. Interestingly, the majority of reported cases were associated with monocytic-lineage leukemias. According to recent reports, tetrasomy 8 is regarded as a poor prognostic factor, and most patients having this abnormality relapsed and died within 1 yr. Here, we report a patient with acute monoblastic leukemia having tetrasomy 8 and a very aggressive disease course.

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Tetrasomy 8 in a patient with acute monoblastic Leukemia

Abstract

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