Temporal Trends of De Novo Malignancy Development After Heart Transplantation

Jong Chan Youn, Josef Stehlik, Amber R. Wilk, Wida Cherikh, In Cheol Kim, Gyeong Hun Park, Lars H. Lund, Howard J. Eisen, Do Young Kim, Sun Ki Lee, Suk Won Choi, Seongwoo Han, Kyu Hyung Ryu, Seok Min Kang, Jon A. Kobashigawa

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64 Citations (Scopus)


Background Malignancy is a concern in cardiac transplant recipients, but the temporal trends of de novo malignancy development are unknown. Objectives The goal of this study was to describe the temporal trends of the incidence, types, and predictors of de novo malignancy in cardiac transplant recipients. Methods The authors analyzed the temporal trends of post-transplant incidence, types, and predictors of malignancy using 17,587 primary adult heart-only transplant recipients from the International Society for Heart and Lung Transplantation registry. The main study outcomes included the incidence of, types of, and time to de novo malignancy. Results The risk of any de novo solid malignancy between years 1 and 5 after transplantation was 10.7%. The cumulative incidence by malignancy type was: skin cancer (7.0%), non-skin solid cancer (4.0%), and lymphoproliferative disorders (0.9%). There was no temporal difference in the time to development according to malignancy type. However, the cumulative incidence of de novo solid malignancy increased from 2000 to 2005 vs. 2006 to 2011 (10.0% vs. 12.4%; p < 0.0001). Survival in patients after de novo malignancy was markedly lower than in patients without malignancy (p < 0.0001). Older recipients and patients who underwent transplantation in the recent era had a higher risk of de novo malignancy. Conclusions More than 10% of adult heart transplant recipients developed de novo malignancy between years 1 and 5 after transplantation, and this outcome was associated with increased mortality. The incidence of post-transplant de novo solid malignancy increased temporally, with the largest increase in skin cancer. Individualized immunosuppression strategies and enhanced cancer screening should be studied to determine whether they can reduce the adverse outcomes of post-transplantation malignancy.

Original languageEnglish
Pages (from-to)40-49
Number of pages10
JournalJournal of the American College of Cardiology
Issue number1
Publication statusPublished - 2018 Jan 2

Bibliographical note

Publisher Copyright:
© 2018 American College of Cardiology Foundation

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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