Tear Cytokines as Biomarkers for Chronic Graft-versus-Host Disease

Ji Won Jung; Soo Jung Han; Mi Kyung Song; Tae im Kim; Eung Kweon Kim; Yoo Hong Min; June Won Cheong; Kyoung Yul Seo

doi:10.1016/j.bbmt.2015.08.020

Tear Cytokines as Biomarkers for Chronic Graft-versus-Host Disease

Ji Won Jung, Soo Jung Han, Mi Kyung Song, Tae im Kim, Eung Kweon Kim, Yoo Hong Min, June Won Cheong, Kyoung Yul Seo

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

We investigated the tear cytokine profiles in patients who underwent stem cell transplantation (SCT) and attempted to evaluate whether tear cytokines are associated with the presence of systemic chronic graft-versus-host disease (GVHD), regardless of ocular GVHD status. We also tested tear cytokines as biomarkers for chronic ocular GVHD severity. Forty-four patients who underwent SCT were enrolled and their diagnosis of chronic GVHD was confirmed. Ocular surface parameters and tear cytokine profiles were evaluated and the correlations between concentrations of cytokines and ocular surface parameters or several chronic ocular GVHD severity scales were evaluated. Tear interleukin (IL)-2, IL-10, IL-17α, interferon (IFN)-γ, IL-6, and tumor necrosis factor (TNF)-α were elevated in patients with chronic systemic GVHD compared with patients without chronic systemic GVHD. Receiver-operating characteristic curve analysis revealed that area under the curve (AUC) values for tear IL-10 (AUC = .795), IL-17α (AUC = .821), IL-6 (AUC = .912), and TNF-α (AUC = .910) were significantly correlated with the presence of chronic GVHD (all P < .001). Tear IL-10, IL-6, and TNF-α showed a stronger correlation with ocular surface parameters than other cytokines and these cytokines also correlated with several chronic ocular GVHD severity scales (all P < .05). Our data suggest the tear cytokines are useful biomarkers for the diagnosis of chronic GVHD after SCT and chronic ocular GVHD severity.

Original language	English
Pages (from-to)	2079-2085
Number of pages	7
Journal	Biology of Blood and Marrow Transplantation
Volume	21
Issue number	12
DOIs	https://doi.org/10.1016/j.bbmt.2015.08.020
Publication status	Published - 2015 Dec

Bibliographical note

Funding Information:
Financial disclosure statement: This study was supported by a grant the from Bio and Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science, ICT & Future Planning, South Korea ( grant no. NRF -2013M3A9D5072551). The supporters had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Conflict of interest statement: The authors have no financial or proprietary interest in any of the products or techniques mentioned in the article.

Publisher Copyright:
© 2015 American Society for Blood and Marrow Transplantation.

All Science Journal Classification (ASJC) codes

Hematology
Transplantation

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10.1016/j.bbmt.2015.08.020

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title = "Tear Cytokines as Biomarkers for Chronic Graft-versus-Host Disease",

abstract = "We investigated the tear cytokine profiles in patients who underwent stem cell transplantation (SCT) and attempted to evaluate whether tear cytokines are associated with the presence of systemic chronic graft-versus-host disease (GVHD), regardless of ocular GVHD status. We also tested tear cytokines as biomarkers for chronic ocular GVHD severity. Forty-four patients who underwent SCT were enrolled and their diagnosis of chronic GVHD was confirmed. Ocular surface parameters and tear cytokine profiles were evaluated and the correlations between concentrations of cytokines and ocular surface parameters or several chronic ocular GVHD severity scales were evaluated. Tear interleukin (IL)-2, IL-10, IL-17α, interferon (IFN)-γ, IL-6, and tumor necrosis factor (TNF)-α were elevated in patients with chronic systemic GVHD compared with patients without chronic systemic GVHD. Receiver-operating characteristic curve analysis revealed that area under the curve (AUC) values for tear IL-10 (AUC = .795), IL-17α (AUC = .821), IL-6 (AUC = .912), and TNF-α (AUC = .910) were significantly correlated with the presence of chronic GVHD (all P < .001). Tear IL-10, IL-6, and TNF-α showed a stronger correlation with ocular surface parameters than other cytokines and these cytokines also correlated with several chronic ocular GVHD severity scales (all P < .05). Our data suggest the tear cytokines are useful biomarkers for the diagnosis of chronic GVHD after SCT and chronic ocular GVHD severity.",

author = "Jung, {Ji Won} and Han, {Soo Jung} and Song, {Mi Kyung} and Kim, {Tae im} and Kim, {Eung Kweon} and Min, {Yoo Hong} and Cheong, {June Won} and Seo, {Kyoung Yul}",

note = "Funding Information: Financial disclosure statement: This study was supported by a grant the from Bio and Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science, ICT & Future Planning, South Korea ( grant no. NRF -2013M3A9D5072551). The supporters had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Conflict of interest statement: The authors have no financial or proprietary interest in any of the products or techniques mentioned in the article. Publisher Copyright: {\textcopyright} 2015 American Society for Blood and Marrow Transplantation.",

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AU - Jung, Ji Won

AU - Han, Soo Jung

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AU - Kim, Tae im

AU - Kim, Eung Kweon

AU - Min, Yoo Hong

AU - Cheong, June Won

AU - Seo, Kyoung Yul

N1 - Funding Information: Financial disclosure statement: This study was supported by a grant the from Bio and Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science, ICT & Future Planning, South Korea ( grant no. NRF -2013M3A9D5072551). The supporters had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Conflict of interest statement: The authors have no financial or proprietary interest in any of the products or techniques mentioned in the article. Publisher Copyright: © 2015 American Society for Blood and Marrow Transplantation.

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N2 - We investigated the tear cytokine profiles in patients who underwent stem cell transplantation (SCT) and attempted to evaluate whether tear cytokines are associated with the presence of systemic chronic graft-versus-host disease (GVHD), regardless of ocular GVHD status. We also tested tear cytokines as biomarkers for chronic ocular GVHD severity. Forty-four patients who underwent SCT were enrolled and their diagnosis of chronic GVHD was confirmed. Ocular surface parameters and tear cytokine profiles were evaluated and the correlations between concentrations of cytokines and ocular surface parameters or several chronic ocular GVHD severity scales were evaluated. Tear interleukin (IL)-2, IL-10, IL-17α, interferon (IFN)-γ, IL-6, and tumor necrosis factor (TNF)-α were elevated in patients with chronic systemic GVHD compared with patients without chronic systemic GVHD. Receiver-operating characteristic curve analysis revealed that area under the curve (AUC) values for tear IL-10 (AUC = .795), IL-17α (AUC = .821), IL-6 (AUC = .912), and TNF-α (AUC = .910) were significantly correlated with the presence of chronic GVHD (all P < .001). Tear IL-10, IL-6, and TNF-α showed a stronger correlation with ocular surface parameters than other cytokines and these cytokines also correlated with several chronic ocular GVHD severity scales (all P < .05). Our data suggest the tear cytokines are useful biomarkers for the diagnosis of chronic GVHD after SCT and chronic ocular GVHD severity.

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Tear Cytokines as Biomarkers for Chronic Graft-versus-Host Disease

Abstract

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