Targeted enzyme-responsive drug carriers: Studies on the delivery of a combination of drugs

Myung Ryul Lee; Kyung Hwa Baek; Hui Juan Jin; Yong Gyu Jung; Injae Shin

doi:10.1002/anie.200353204

Targeted enzyme-responsive drug carriers: Studies on the delivery of a combination of drugs

Myung Ryul Lee, Kyung Hwa Baek, Hui Juan Jin, Yong Gyu Jung, Injae Shin

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

Double whammy: Effective and selective killing of E. coli cells containing a specific enzyme was achieved by using targeted enzyme-responsive drug carriers (see picture) that release free drugs in a stringently controlled manner. The carrier lowered the effective concentration of drug needed to kill the bacteria. The system could also be modified to deliver a combination of two drugs.

Original language	English
Pages (from-to)	1675-1678
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	13
DOIs	https://doi.org/10.1002/anie.200353204
Publication status	Published - 2004 Mar 19

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

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10.1002/anie.200353204

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abstract = "Double whammy: Effective and selective killing of E. coli cells containing a specific enzyme was achieved by using targeted enzyme-responsive drug carriers (see picture) that release free drugs in a stringently controlled manner. The carrier lowered the effective concentration of drug needed to kill the bacteria. The system could also be modified to deliver a combination of two drugs.",

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Targeted enzyme-responsive drug carriers: Studies on the delivery of a combination of drugs

Abstract

All Science Journal Classification (ASJC) codes

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