T 1 and T 2 dual-mode MRI contrast agent for enhancing accuracy by engineered nanomaterials

Tae Hyun Shin; Jin Sil Choi; Seokhwan Yun; Il Sun Kim; Ho Taek Song; Youngmee Kim; Kook In Park; Jinwoo Cheon

doi:10.1021/nn405977t

T ₁ and T ₂ dual-mode MRI contrast agent for enhancing accuracy by engineered nanomaterials

Tae Hyun Shin, Jin Sil Choi, Seokhwan Yun, Il Sun Kim, Ho Taek Song, Youngmee Kim, Kook In Park, Jinwoo Cheon

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

179 Citations (Scopus)

Abstract

One of the holy grails in biomedical imaging technology is to achieve accurate imaging of biological targets. The development of sophisticated instrumentation and the use of contrast agents have improved the accuracy of biomedical imaging. However, the issue of false imaging remains a problem. Here, we developed a dual-mode artifact filtering nanoparticle imaging agent (AFIA) that comprises a combination of paramagnetic and superparamagnetic nanomaterials. This AFIA has the ability to perform "AND logic gate" algorithm to eliminate false errors (artifacts) from the raw images to enhance accuracy of the MRI. We confirm the artifact filtering capability of AFIA in MRI phantoms and further demonstrate that artifact-free imaging of stem cell migration is possible in vivo.

Original language	English
Pages (from-to)	3393-3401
Number of pages	9
Journal	ACS Nano
Volume	8
Issue number	4
DOIs	https://doi.org/10.1021/nn405977t
Publication status	Published - 2014 Apr 22

All Science Journal Classification (ASJC) codes

Materials Science(all)
Engineering(all)
Physics and Astronomy(all)

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10.1021/nn405977t

Cite this

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abstract = "One of the holy grails in biomedical imaging technology is to achieve accurate imaging of biological targets. The development of sophisticated instrumentation and the use of contrast agents have improved the accuracy of biomedical imaging. However, the issue of false imaging remains a problem. Here, we developed a dual-mode artifact filtering nanoparticle imaging agent (AFIA) that comprises a combination of paramagnetic and superparamagnetic nanomaterials. This AFIA has the ability to perform {"}AND logic gate{"} algorithm to eliminate false errors (artifacts) from the raw images to enhance accuracy of the MRI. We confirm the artifact filtering capability of AFIA in MRI phantoms and further demonstrate that artifact-free imaging of stem cell migration is possible in vivo.",

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T1 - T 1 and T 2 dual-mode MRI contrast agent for enhancing accuracy by engineered nanomaterials

AU - Shin, Tae Hyun

AU - Choi, Jin Sil

AU - Yun, Seokhwan

AU - Kim, Il Sun

AU - Song, Ho Taek

AU - Kim, Youngmee

AU - Park, Kook In

AU - Cheon, Jinwoo

PY - 2014/4/22

Y1 - 2014/4/22

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AB - One of the holy grails in biomedical imaging technology is to achieve accurate imaging of biological targets. The development of sophisticated instrumentation and the use of contrast agents have improved the accuracy of biomedical imaging. However, the issue of false imaging remains a problem. Here, we developed a dual-mode artifact filtering nanoparticle imaging agent (AFIA) that comprises a combination of paramagnetic and superparamagnetic nanomaterials. This AFIA has the ability to perform "AND logic gate" algorithm to eliminate false errors (artifacts) from the raw images to enhance accuracy of the MRI. We confirm the artifact filtering capability of AFIA in MRI phantoms and further demonstrate that artifact-free imaging of stem cell migration is possible in vivo.

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T ₁ and T ₂ dual-mode MRI contrast agent for enhancing accuracy by engineered nanomaterials

Abstract

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