Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid

Jaemoon Yang; Tong Il Lee; Jaemin Lee; Eun Kyung Lim; Woochan Hyung; Choong Hwan Lee; Yong Jin Song; Jin Suck Suh; Ho Geun Yoon; Yong Min Huh; Seungjoo Haam

doi:10.1021/cm070495s

Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid

Jaemoon Yang, Tong Il Lee, Jaemin Lee, Eun Kyung Lim, Woochan Hyung, Choong Hwan Lee, Yong Jin Song, Jin Suck Suh, Ho Geun Yoon, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Diagnosis of cancer in the early stages requires sensitive magnetic resonance (MR) probes to detect low concentrations of magnetic substances. In this study, ultrasensitive magnetic resonance contrast agents (UMRCAs) composed of magnetic nanocrystals and amphiphilic block copolymers were synthesized for cancer detection using polyethylene glycol and fatty acid. The chemical structures and the compositions of PEGylated magnetic nanoparticles were analyzed. UMRCAs displayed remarkable colloidal stability and high sensitivity as MR probes. Furthermore, UMRCAs exhibited low cytotoxicity and excellent cancer detection ability in an in vivo animal model.

Original language	English
Pages (from-to)	3870-3876
Number of pages	7
Journal	Chemistry of Materials
Volume	19
Issue number	16
DOIs	https://doi.org/10.1021/cm070495s
Publication status	Published - 2007 Aug 7

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)
Materials Chemistry

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10.1021/cm070495s

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title = "Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid",

abstract = "Diagnosis of cancer in the early stages requires sensitive magnetic resonance (MR) probes to detect low concentrations of magnetic substances. In this study, ultrasensitive magnetic resonance contrast agents (UMRCAs) composed of magnetic nanocrystals and amphiphilic block copolymers were synthesized for cancer detection using polyethylene glycol and fatty acid. The chemical structures and the compositions of PEGylated magnetic nanoparticles were analyzed. UMRCAs displayed remarkable colloidal stability and high sensitivity as MR probes. Furthermore, UMRCAs exhibited low cytotoxicity and excellent cancer detection ability in an in vivo animal model.",

author = "Jaemoon Yang and Lee, {Tong Il} and Jaemin Lee and Lim, {Eun Kyung} and Woochan Hyung and Lee, {Choong Hwan} and Song, {Yong Jin} and Suh, {Jin Suck} and Yoon, {Ho Geun} and Huh, {Yong Min} and Seungjoo Haam",

year = "2007",

month = aug,

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doi = "10.1021/cm070495s",

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T1 - Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid

AU - Yang, Jaemoon

AU - Lee, Tong Il

AU - Lee, Jaemin

AU - Lim, Eun Kyung

AU - Hyung, Woochan

AU - Lee, Choong Hwan

AU - Song, Yong Jin

AU - Suh, Jin Suck

AU - Yoon, Ho Geun

AU - Huh, Yong Min

AU - Haam, Seungjoo

PY - 2007/8/7

Y1 - 2007/8/7

N2 - Diagnosis of cancer in the early stages requires sensitive magnetic resonance (MR) probes to detect low concentrations of magnetic substances. In this study, ultrasensitive magnetic resonance contrast agents (UMRCAs) composed of magnetic nanocrystals and amphiphilic block copolymers were synthesized for cancer detection using polyethylene glycol and fatty acid. The chemical structures and the compositions of PEGylated magnetic nanoparticles were analyzed. UMRCAs displayed remarkable colloidal stability and high sensitivity as MR probes. Furthermore, UMRCAs exhibited low cytotoxicity and excellent cancer detection ability in an in vivo animal model.

AB - Diagnosis of cancer in the early stages requires sensitive magnetic resonance (MR) probes to detect low concentrations of magnetic substances. In this study, ultrasensitive magnetic resonance contrast agents (UMRCAs) composed of magnetic nanocrystals and amphiphilic block copolymers were synthesized for cancer detection using polyethylene glycol and fatty acid. The chemical structures and the compositions of PEGylated magnetic nanoparticles were analyzed. UMRCAs displayed remarkable colloidal stability and high sensitivity as MR probes. Furthermore, UMRCAs exhibited low cytotoxicity and excellent cancer detection ability in an in vivo animal model.

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JO - Chemistry of Materials

JF - Chemistry of Materials

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Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid

Abstract

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