Synthesis of substituted imidazolidin-2-ones as aminoacyl-tRNA synthase inhibitors

Heesung Eum, Yuno Lee, Songmi Kim, Ayoung Baek, Minky Son, Keun Woo Lee, Seung Whan Ko, Sunghoon Kim, Sae Young Yun, Won Koo Lee, Hyun Joon Ha

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Substituted imidazolidin-2-ones deduced as potential inhibitors of IleRS by docking simulations were synthesized from an aziridine-2-carboxaldehyde. Reductive amination of an aziridine-2-carboxaldehyde with dipeptides for the substituents at N1 and followed by aziridine-ring expansion with triphosgene afforded 4-chloromethylimidazolidin-2-ones whose chloride were further manipulated towards phenylurea, pyrimidin-2-yl-urea or benzenesulfonamide at C4.

Original languageEnglish
Pages (from-to)611-614
Number of pages4
JournalBulletin of the Korean Chemical Society
Issue number3
Publication statusPublished - 2010 Mar

All Science Journal Classification (ASJC) codes

  • Chemistry(all)


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