Synthesis of substituted imidazolidin-2-ones as aminoacyl-tRNA synthase inhibitors

Heesung Eum; Yuno Lee; Songmi Kim; Ayoung Baek; Minky Son; Keun Woo Lee; Seung Whan Ko; Sunghoon Kim; Sae Young Yun; Won Koo Lee; Hyun Joon Ha

doi:10.5012/bkcs.2010.31.03.611

Synthesis of substituted imidazolidin-2-ones as aminoacyl-tRNA synthase inhibitors

Heesung Eum, Yuno Lee, Songmi Kim, Ayoung Baek, Minky Son, Keun Woo Lee, Seung Whan Ko, Sunghoon Kim, Sae Young Yun, Won Koo Lee, Hyun Joon Ha

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Substituted imidazolidin-2-ones deduced as potential inhibitors of IleRS by docking simulations were synthesized from an aziridine-2-carboxaldehyde. Reductive amination of an aziridine-2-carboxaldehyde with dipeptides for the substituents at N1 and followed by aziridine-ring expansion with triphosgene afforded 4-chloromethylimidazolidin-2-ones whose chloride were further manipulated towards phenylurea, pyrimidin-2-yl-urea or benzenesulfonamide at C4.

Original language	English
Pages (from-to)	611-614
Number of pages	4
Journal	Bulletin of the Korean Chemical Society
Volume	31
Issue number	3
DOIs	https://doi.org/10.5012/bkcs.2010.31.03.611
Publication status	Published - 2010 Mar

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.5012/bkcs.2010.31.03.611

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title = "Synthesis of substituted imidazolidin-2-ones as aminoacyl-tRNA synthase inhibitors",

abstract = "Substituted imidazolidin-2-ones deduced as potential inhibitors of IleRS by docking simulations were synthesized from an aziridine-2-carboxaldehyde. Reductive amination of an aziridine-2-carboxaldehyde with dipeptides for the substituents at N1 and followed by aziridine-ring expansion with triphosgene afforded 4-chloromethylimidazolidin-2-ones whose chloride were further manipulated towards phenylurea, pyrimidin-2-yl-urea or benzenesulfonamide at C4.",

author = "Heesung Eum and Yuno Lee and Songmi Kim and Ayoung Baek and Minky Son and Lee, {Keun Woo} and Ko, {Seung Whan} and Sunghoon Kim and Yun, {Sae Young} and Lee, {Won Koo} and Ha, {Hyun Joon}",

year = "2010",

month = mar,

doi = "10.5012/bkcs.2010.31.03.611",

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T1 - Synthesis of substituted imidazolidin-2-ones as aminoacyl-tRNA synthase inhibitors

AU - Eum, Heesung

AU - Lee, Yuno

AU - Kim, Songmi

AU - Baek, Ayoung

AU - Son, Minky

AU - Lee, Keun Woo

AU - Ko, Seung Whan

AU - Kim, Sunghoon

AU - Yun, Sae Young

AU - Lee, Won Koo

AU - Ha, Hyun Joon

PY - 2010/3

Y1 - 2010/3

N2 - Substituted imidazolidin-2-ones deduced as potential inhibitors of IleRS by docking simulations were synthesized from an aziridine-2-carboxaldehyde. Reductive amination of an aziridine-2-carboxaldehyde with dipeptides for the substituents at N1 and followed by aziridine-ring expansion with triphosgene afforded 4-chloromethylimidazolidin-2-ones whose chloride were further manipulated towards phenylurea, pyrimidin-2-yl-urea or benzenesulfonamide at C4.

AB - Substituted imidazolidin-2-ones deduced as potential inhibitors of IleRS by docking simulations were synthesized from an aziridine-2-carboxaldehyde. Reductive amination of an aziridine-2-carboxaldehyde with dipeptides for the substituents at N1 and followed by aziridine-ring expansion with triphosgene afforded 4-chloromethylimidazolidin-2-ones whose chloride were further manipulated towards phenylurea, pyrimidin-2-yl-urea or benzenesulfonamide at C4.

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M3 - Article

AN - SCOPUS:77951792750

SN - 0253-2964

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JO - Bulletin of the Korean Chemical Society

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ER -

Synthesis of substituted imidazolidin-2-ones as aminoacyl-tRNA synthase inhibitors

Abstract

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