Synthesis of polymers for a gene carrier by the ester-amide exchange method

Shigeto Fukushima; Naoki Kanayama; Kanjiro Miyata; Younsoo Bae; Masataka Nakanishi; Woo Dong Jang; Nobuhiro Nishiyama; Yuichi Yamasaki; Kazunori Kataoka

Synthesis of polymers for a gene carrier by the ester-amide exchange method

Shigeto Fukushima, Naoki Kanayama, Kanjiro Miyata, Younsoo Bae, Masataka Nakanishi, Woo Dong Jang, Nobuhiro Nishiyama, Yuichi Yamasaki, Kazunori Kataoka

Department of Chemistry

Research output: Contribution to conference › Paper › peer-review

Abstract

Polyethylene glycol-polycation block copolymers, in which various kind of cationic side chains were introduced, were successfully synthesized by aminolysis of benzyl ester of polyethylene glycol-poly(β- benzyl-L-aspartate) block copolymer(PEG-PBLA)(ester-amide exchange method). Among them, some block copolymers showed the high transfection efficiency, and the mechanism and the characteristics of the ester-amide exchange reaction were investigated. This method is a very useful tool for design of non-viral gene carriers.

Original language	English
Pages	2208
Number of pages	1
Publication status	Published - 2005
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: 2005 May 25 → 2005 May 27

Other

Other	54th SPSJ Annual Meeting 2005
Country/Territory	Japan
City	Yokohama
Period	05/5/25 → 05/5/27

All Science Journal Classification (ASJC) codes

Engineering(all)

Cite this

@conference{cd71960b089549a794e472b559f47fd0,

title = "Synthesis of polymers for a gene carrier by the ester-amide exchange method",

abstract = "Polyethylene glycol-polycation block copolymers, in which various kind of cationic side chains were introduced, were successfully synthesized by aminolysis of benzyl ester of polyethylene glycol-poly(β- benzyl-L-aspartate) block copolymer(PEG-PBLA)(ester-amide exchange method). Among them, some block copolymers showed the high transfection efficiency, and the mechanism and the characteristics of the ester-amide exchange reaction were investigated. This method is a very useful tool for design of non-viral gene carriers.",

author = "Shigeto Fukushima and Naoki Kanayama and Kanjiro Miyata and Younsoo Bae and Masataka Nakanishi and Jang, {Woo Dong} and Nobuhiro Nishiyama and Yuichi Yamasaki and Kazunori Kataoka",

year = "2005",

language = "English",

pages = "2208",

note = "54th SPSJ Annual Meeting 2005 ; Conference date: 25-05-2005 Through 27-05-2005",

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TY - CONF

T1 - Synthesis of polymers for a gene carrier by the ester-amide exchange method

AU - Fukushima, Shigeto

AU - Kanayama, Naoki

AU - Miyata, Kanjiro

AU - Bae, Younsoo

AU - Nakanishi, Masataka

AU - Jang, Woo Dong

AU - Nishiyama, Nobuhiro

AU - Yamasaki, Yuichi

AU - Kataoka, Kazunori

PY - 2005

Y1 - 2005

N2 - Polyethylene glycol-polycation block copolymers, in which various kind of cationic side chains were introduced, were successfully synthesized by aminolysis of benzyl ester of polyethylene glycol-poly(β- benzyl-L-aspartate) block copolymer(PEG-PBLA)(ester-amide exchange method). Among them, some block copolymers showed the high transfection efficiency, and the mechanism and the characteristics of the ester-amide exchange reaction were investigated. This method is a very useful tool for design of non-viral gene carriers.

AB - Polyethylene glycol-polycation block copolymers, in which various kind of cationic side chains were introduced, were successfully synthesized by aminolysis of benzyl ester of polyethylene glycol-poly(β- benzyl-L-aspartate) block copolymer(PEG-PBLA)(ester-amide exchange method). Among them, some block copolymers showed the high transfection efficiency, and the mechanism and the characteristics of the ester-amide exchange reaction were investigated. This method is a very useful tool for design of non-viral gene carriers.

UR - http://www.scopus.com/inward/record.url?scp=33645643486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645643486&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645643486

SP - 2208

T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Synthesis of polymers for a gene carrier by the ester-amide exchange method

Abstract

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All Science Journal Classification (ASJC) codes

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