Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives

Youngjae Kim, Minjoo Kim, Mooseong Park, Jinsung Tae, Du Jong Baek, Ki Duk Park, Hyunah Choo

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.

Original languageEnglish
Pages (from-to)5074-5084
Number of pages11
Issue number3
Publication statusPublished - 2015 Mar 1

Bibliographical note

Publisher Copyright:
© 2015 by the authors; licensee MDPI.

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of 'Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives'. Together they form a unique fingerprint.

Cite this