Synthesis of daumone derivatives and their antiangiogenic activities on chorioallantoic membrane

Jeremy Ricci; Dongguk Min; Miyeon Oh; Hyenchong Lim; Won Yoon Chung; Kwang Kyun Park; Mankil Jung

doi:10.2174/1573406411666150514100630

Synthesis of daumone derivatives and their antiangiogenic activities on chorioallantoic membrane

Jeremy Ricci, Dongguk Min, Miyeon Oh, Hyenchong Lim, Won Yoon Chung, Kwang Kyun Park, Mankil Jung

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

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Abstract

Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.

Original language	English
Pages (from-to)	747-752
Number of pages	6
Journal	Medicinal Chemistry
Volume	11
Issue number	8
DOIs	https://doi.org/10.2174/1573406411666150514100630
Publication status	Published - 2015 Dec 1

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© 2015 Bentham Science Publishers.

All Science Journal Classification (ASJC) codes

Drug Discovery

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title = "Synthesis of daumone derivatives and their antiangiogenic activities on chorioallantoic membrane",

abstract = "Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.",

author = "Jeremy Ricci and Dongguk Min and Miyeon Oh and Hyenchong Lim and Chung, {Won Yoon} and Park, {Kwang Kyun} and Mankil Jung",

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AU - Ricci, Jeremy

AU - Min, Dongguk

AU - Oh, Miyeon

AU - Lim, Hyenchong

AU - Chung, Won Yoon

AU - Park, Kwang Kyun

AU - Jung, Mankil

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.

AB - Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.

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Synthesis of daumone derivatives and their antiangiogenic activities on chorioallantoic membrane

Abstract

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