Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

Eun Young Song; Navneet Kaur; Mi Young Park; Yinglan Jin; Kyeong Lee; Guncheol Kim; Ki Youn Lee; Jee Sun Yang; Jae Hong Shin; Ky Youb Nam; Kyoung Tai No; Gyoonhee Han

doi:10.1016/j.ejmech.2007.10.008

Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

Eun Young Song, Navneet Kaur, Mi Young Park, Yinglan Jin, Kyeong Lee, Guncheol Kim, Ki Youn Lee, Jee Sun Yang, Jae Hong Shin, Ky Youb Nam, Kyoung Tai No, Gyoonhee Han

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.

Original language	English
Pages (from-to)	1519-1524
Number of pages	6
Journal	European Journal of Medicinal Chemistry
Volume	43
Issue number	7
DOIs	https://doi.org/10.1016/j.ejmech.2007.10.008
Publication status	Published - 2008 Jul

Bibliographical note

Funding Information:
This research was supported by the Korea Science and Engineering Foundation (KOSEF) grant (M10601000155) and Seoul R&BD Program (10541), Korea.

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery
Organic Chemistry

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10.1016/j.ejmech.2007.10.008

Cite this

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title = "Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor",

abstract = "A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.",

author = "Song, {Eun Young} and Navneet Kaur and Park, {Mi Young} and Yinglan Jin and Kyeong Lee and Guncheol Kim and Lee, {Ki Youn} and Yang, {Jee Sun} and Shin, {Jae Hong} and Nam, {Ky Youb} and No, {Kyoung Tai} and Gyoonhee Han",

note = "Funding Information: This research was supported by the Korea Science and Engineering Foundation (KOSEF) grant (M10601000155) and Seoul R&BD Program (10541), Korea.",

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doi = "10.1016/j.ejmech.2007.10.008",

language = "English",

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AU - Song, Eun Young

AU - Kaur, Navneet

AU - Park, Mi Young

AU - Jin, Yinglan

AU - Lee, Kyeong

AU - Kim, Guncheol

AU - Lee, Ki Youn

AU - Yang, Jee Sun

AU - Shin, Jae Hong

AU - Nam, Ky Youb

AU - No, Kyoung Tai

AU - Han, Gyoonhee

N1 - Funding Information: This research was supported by the Korea Science and Engineering Foundation (KOSEF) grant (M10601000155) and Seoul R&BD Program (10541), Korea.

PY - 2008/7

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Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

Abstract

Bibliographical note

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