Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

Eun Young Song, Navneet Kaur, Mi Young Park, Yinglan Jin, Kyeong Lee, Guncheol Kim, Ki Youn Lee, Jee Sun Yang, Jae Hong Shin, Ky Youb Nam, Kyoung Tai No, Gyoonhee Han

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67 Citations (Scopus)


A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.

Original languageEnglish
Pages (from-to)1519-1524
Number of pages6
JournalEuropean Journal of Medicinal Chemistry
Issue number7
Publication statusPublished - 2008 Jul

Bibliographical note

Funding Information:
This research was supported by the Korea Science and Engineering Foundation (KOSEF) grant (M10601000155) and Seoul R&BD Program (10541), Korea.

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry


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