Synthesis of a fluorescent and star-shaped 4-arm PEG with different functional groups at its ends

Dong Ik Lee; Chan Jin Kim; Chang Ha Lee; Ik Sung Ahn

doi:10.1016/j.jiec.2012.01.010

Synthesis of a fluorescent and star-shaped 4-arm PEG with different functional groups at its ends

Dong Ik Lee, Chan Jin Kim, Chang Ha Lee, Ik Sung Ahn

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Dityrosine (DY), which is fluorescent and biocompatible, has multiple functional groups, including two amine and two carboxylic acid groups. By conjugating PEG arms to DY, we successfully synthesized a star-shaped 4-arm PEG with two carboxylic acid and two amine groups at its four ends. Two different kinds of molecules could be further linked to this 4-arm PEG.The chemical structures and molecular weights of the intermediate 2-arm PEG and 4-arm PEG were determined by ¹H NMR spectroscopy and matrix assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS).

Original language	English
Pages (from-to)	1186-1190
Number of pages	5
Journal	Journal of Industrial and Engineering Chemistry
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/j.jiec.2012.01.010
Publication status	Published - 2012 May 25

Bibliographical note

Funding Information:
This study was supported by the Advanced Biomass R&D Center (ABC) of Korea (Grant No. 2010-0029734 ) funded by the Ministry of Education, Science and Technology .

All Science Journal Classification (ASJC) codes

Chemical Engineering(all)

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10.1016/j.jiec.2012.01.010

Cite this

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title = "Synthesis of a fluorescent and star-shaped 4-arm PEG with different functional groups at its ends",

abstract = "Dityrosine (DY), which is fluorescent and biocompatible, has multiple functional groups, including two amine and two carboxylic acid groups. By conjugating PEG arms to DY, we successfully synthesized a star-shaped 4-arm PEG with two carboxylic acid and two amine groups at its four ends. Two different kinds of molecules could be further linked to this 4-arm PEG.The chemical structures and molecular weights of the intermediate 2-arm PEG and 4-arm PEG were determined by 1H NMR spectroscopy and matrix assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS).",

author = "Lee, {Dong Ik} and Kim, {Chan Jin} and Lee, {Chang Ha} and Ahn, {Ik Sung}",

note = "Funding Information: This study was supported by the Advanced Biomass R&D Center (ABC) of Korea (Grant No. 2010-0029734 ) funded by the Ministry of Education, Science and Technology .",

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doi = "10.1016/j.jiec.2012.01.010",

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T1 - Synthesis of a fluorescent and star-shaped 4-arm PEG with different functional groups at its ends

AU - Lee, Dong Ik

AU - Kim, Chan Jin

AU - Lee, Chang Ha

AU - Ahn, Ik Sung

N1 - Funding Information: This study was supported by the Advanced Biomass R&D Center (ABC) of Korea (Grant No. 2010-0029734 ) funded by the Ministry of Education, Science and Technology .

PY - 2012/5/25

Y1 - 2012/5/25

N2 - Dityrosine (DY), which is fluorescent and biocompatible, has multiple functional groups, including two amine and two carboxylic acid groups. By conjugating PEG arms to DY, we successfully synthesized a star-shaped 4-arm PEG with two carboxylic acid and two amine groups at its four ends. Two different kinds of molecules could be further linked to this 4-arm PEG.The chemical structures and molecular weights of the intermediate 2-arm PEG and 4-arm PEG were determined by 1H NMR spectroscopy and matrix assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS).

AB - Dityrosine (DY), which is fluorescent and biocompatible, has multiple functional groups, including two amine and two carboxylic acid groups. By conjugating PEG arms to DY, we successfully synthesized a star-shaped 4-arm PEG with two carboxylic acid and two amine groups at its four ends. Two different kinds of molecules could be further linked to this 4-arm PEG.The chemical structures and molecular weights of the intermediate 2-arm PEG and 4-arm PEG were determined by 1H NMR spectroscopy and matrix assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS).

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Synthesis of a fluorescent and star-shaped 4-arm PEG with different functional groups at its ends

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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