Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities

Sang Sup Jew; Boon Saeng Park; Doo Yeon Lim; Myoung Goo Kim; In Kwon Chung; Joo Hee Kim; Chung Il Hong; Joon Kyum Kim; Hong Jun Park; Jun Hee Lee; Hyeung Geun Park

doi:10.1016/S0960-894X(02)01041-7

Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities

Sang Sup Jew, Boon Saeng Park, Doo Yeon Lim, Myoung Goo Kim, In Kwon Chung, Joo Hee Kim, Chung Il Hong, Joon Kyum Kim, Hong Jun Park, Jun Hee Lee, Hyeung Geun Park

Department of Systems Biology

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.

Original language	English
Pages (from-to)	609-612
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	4
DOIs	https://doi.org/10.1016/S0960-894X(02)01041-7
Publication status	Published - 2003 Feb

Bibliographical note

Funding Information:
This research was supported by grants of the Good Health R&D project, from the Ministry of Health & Welfare, ROK (HMP-00-B-21500-00115 and 02-PJ2-PG10-21503-0006).

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(02)01041-7

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title = "Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities",

abstract = "Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.",

author = "Jew, {Sang Sup} and Park, {Boon Saeng} and Lim, {Doo Yeon} and Kim, {Myoung Goo} and Chung, {In Kwon} and Kim, {Joo Hee} and Hong, {Chung Il} and Kim, {Joon Kyum} and Park, {Hong Jun} and Lee, {Jun Hee} and Park, {Hyeung Geun}",

note = "Funding Information: This research was supported by grants of the Good Health R&D project, from the Ministry of Health & Welfare, ROK (HMP-00-B-21500-00115 and 02-PJ2-PG10-21503-0006).",

year = "2003",

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doi = "10.1016/S0960-894X(02)01041-7",

language = "English",

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T1 - Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities

AU - Jew, Sang Sup

AU - Park, Boon Saeng

AU - Lim, Doo Yeon

AU - Kim, Myoung Goo

AU - Chung, In Kwon

AU - Kim, Joo Hee

AU - Hong, Chung Il

AU - Kim, Joon Kyum

AU - Park, Hong Jun

AU - Lee, Jun Hee

AU - Park, Hyeung Geun

N1 - Funding Information: This research was supported by grants of the Good Health R&D project, from the Ministry of Health & Welfare, ROK (HMP-00-B-21500-00115 and 02-PJ2-PG10-21503-0006).

PY - 2003/2

Y1 - 2003/2

N2 - Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.

AB - Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.

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Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities

Abstract

Bibliographical note

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