Synthesis of 2,3-disubstituted indole on solid phase by the fischer indole synthesis

Han Seo Mun; Won Hun Ham; Jin Hyun Jeong

doi:10.1021/cc049922e

Synthesis of 2,3-disubstituted indole on solid phase by the fischer indole synthesis

Han Seo Mun, Won Hun Ham, Jin Hyun Jeong

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

2,3-Disubstituted indoles were synthesized by solid-phase reaction using the Fischer indole synthesis. A "traceless" silicon linker was employed with the silicon - carbon bonding being cleaved with TFA. An oxygen atom was placed into the middle of the spacer/linker so as to enhance solid-phase synthesis by better solvation.

Original language	English
Pages (from-to)	130-135
Number of pages	6
Journal	Journal of Combinatorial Chemistry
Volume	7
Issue number	1
DOIs	https://doi.org/10.1021/cc049922e
Publication status	Published - 2005 Jan

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1021/cc049922e

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title = "Synthesis of 2,3-disubstituted indole on solid phase by the fischer indole synthesis",

abstract = "2,3-Disubstituted indoles were synthesized by solid-phase reaction using the Fischer indole synthesis. A {"}traceless{"} silicon linker was employed with the silicon - carbon bonding being cleaved with TFA. An oxygen atom was placed into the middle of the spacer/linker so as to enhance solid-phase synthesis by better solvation.",

author = "Mun, {Han Seo} and Ham, {Won Hun} and Jeong, {Jin Hyun}",

year = "2005",

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doi = "10.1021/cc049922e",

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AU - Mun, Han Seo

AU - Ham, Won Hun

AU - Jeong, Jin Hyun

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N2 - 2,3-Disubstituted indoles were synthesized by solid-phase reaction using the Fischer indole synthesis. A "traceless" silicon linker was employed with the silicon - carbon bonding being cleaved with TFA. An oxygen atom was placed into the middle of the spacer/linker so as to enhance solid-phase synthesis by better solvation.

AB - 2,3-Disubstituted indoles were synthesized by solid-phase reaction using the Fischer indole synthesis. A "traceless" silicon linker was employed with the silicon - carbon bonding being cleaved with TFA. An oxygen atom was placed into the middle of the spacer/linker so as to enhance solid-phase synthesis by better solvation.

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Synthesis of 2,3-disubstituted indole on solid phase by the fischer indole synthesis

Abstract

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