Synthesis, characterization and biological evaluation of anti-cancer indolizine derivatives via inhibiting β-catenin activity and activating p53

Seong Hee Moon; Youngeun Jung; Seong Hwan Kim; Ikyon Kim

doi:10.1016/j.bmcl.2015.11.021

Synthesis, characterization and biological evaluation of anti-cancer indolizine derivatives via inhibiting β-catenin activity and activating p53

Seong Hee Moon, Youngeun Jung, Seong Hwan Kim, Ikyon Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Diversity-oriented construction of new indolizine scaffolds was accomplished by utilizing domino Knoevenagel condensation/intramolecular aldol cyclization. Biological evaluation revealed anticancer activity of these compounds through inhibition of β-catenin and activation of p53.

Original language	English
Pages (from-to)	110-113
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2015.11.021
Publication status	Published - 2016 Jan 1

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIP) (2014R1A2A1A11050491) (to I.K.) and the Korea Research Institute of Chemical Technology project grant (SI1505) (to S.K.).

Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

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10.1016/j.bmcl.2015.11.021

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AU - Kim, Ikyon

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Synthesis, characterization and biological evaluation of anti-cancer indolizine derivatives via inhibiting β-catenin activity and activating p53

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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