Synthesis and evaluation of selenoflavones that have potential neuroprotective effects

Yong Sung Choi, Yoon Jung Kim, Ju Yeun Lee, Jinu Lee, Jin Hyun Jeong

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We synthesized selenoflavones and evaluated their physicochemical properties and antioxidant effects. When oxygen was substituted with selenium, the compounds exhibited improved polarity and lipophilicity, implying that this change could lead to better BBB penetration. Selenoflavones revealed more potent antioxidant activity in our in-vitro assay. This suggests that selenoflavones would be more druggable than flavones and have a better potential as a neuroprotective agent.

Original languageEnglish
Pages (from-to)2794-2805
Number of pages12
Issue number12
Publication statusPublished - 2014

Bibliographical note

Publisher Copyright:
© 2014 The Japan Institute of Heterocyclic Chemistry.

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry


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