Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates

Milan Balaz; Andrea E. Holmes; Michele Benedetti; Pamela C. Rodriguez; Nina Berova; Koji Nakanishi; Gloria Proni

doi:10.1021/ja043373z

Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates

Milan Balaz, Andrea E. Holmes, Michele Benedetti, Pamela C. Rodriguez, Nina Berova, Koji Nakanishi, Gloria Proni

Integrated Sciences and Engineering Division

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The preparation and circular dichroic (CD) studies of self-complimentary 8-mer DNA sequences with a porphyrin at the 3- end are presented. Electronic interaction between the two porphyrins (the interchromophoric distance is in the range of 28-40 Å), attached to both ends of the double-stranded helix, gives rise to a long-range exciton-coupled CD in the visible region (400-450 nm). The porphyrin chromophores act as sensitive probes of geometrical changes in the DNA backbone and sensitively reflect the double-strand to single-strand transition. This study demonstrates the possibility of using exciton-coupled porphyrin CDs for conformational studies of DNA.

Original language	English
Pages (from-to)	4172-4173
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	12
DOIs	https://doi.org/10.1021/ja043373z
Publication status	Published - 2005 Mar 30

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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title = "Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates",

abstract = "The preparation and circular dichroic (CD) studies of self-complimentary 8-mer DNA sequences with a porphyrin at the 3- end are presented. Electronic interaction between the two porphyrins (the interchromophoric distance is in the range of 28-40 {\AA}), attached to both ends of the double-stranded helix, gives rise to a long-range exciton-coupled CD in the visible region (400-450 nm). The porphyrin chromophores act as sensitive probes of geometrical changes in the DNA backbone and sensitively reflect the double-strand to single-strand transition. This study demonstrates the possibility of using exciton-coupled porphyrin CDs for conformational studies of DNA.",

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T1 - Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates

AU - Balaz, Milan

AU - Holmes, Andrea E.

AU - Benedetti, Michele

AU - Rodriguez, Pamela C.

AU - Berova, Nina

AU - Nakanishi, Koji

AU - Proni, Gloria

PY - 2005/3/30

Y1 - 2005/3/30

N2 - The preparation and circular dichroic (CD) studies of self-complimentary 8-mer DNA sequences with a porphyrin at the 3- end are presented. Electronic interaction between the two porphyrins (the interchromophoric distance is in the range of 28-40 Å), attached to both ends of the double-stranded helix, gives rise to a long-range exciton-coupled CD in the visible region (400-450 nm). The porphyrin chromophores act as sensitive probes of geometrical changes in the DNA backbone and sensitively reflect the double-strand to single-strand transition. This study demonstrates the possibility of using exciton-coupled porphyrin CDs for conformational studies of DNA.

AB - The preparation and circular dichroic (CD) studies of self-complimentary 8-mer DNA sequences with a porphyrin at the 3- end are presented. Electronic interaction between the two porphyrins (the interchromophoric distance is in the range of 28-40 Å), attached to both ends of the double-stranded helix, gives rise to a long-range exciton-coupled CD in the visible region (400-450 nm). The porphyrin chromophores act as sensitive probes of geometrical changes in the DNA backbone and sensitively reflect the double-strand to single-strand transition. This study demonstrates the possibility of using exciton-coupled porphyrin CDs for conformational studies of DNA.

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Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates

Abstract

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