TY - JOUR
T1 - Synthesis and Characterization of a New Class of Triazoles Containing Bicyclic Silaheterocycles
AU - Wang, Tengjiao
AU - Cho, Hyeon Mo
AU - Lee, Myong Euy
N1 - Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2017/5/2
Y1 - 2017/5/2
N2 - A new class of bicyclic silaheterocycles, 6,6-dimethyl-2-aryl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3,5]thiazasilines, which could be developed as potential sila-drugs. The reactions of several 3-aryl-5-mercapto-1,2,4-triazoles with bis(chloromethyl)dimethylsilane under basic conditions gave high yields of bicyclic products. Reaction, product workup and isolation were streamlined without requiring an anhydrous solvent, inert gas or chromatographic purification. The products were structurally characterized by single-crystal X-ray diffraction.
AB - A new class of bicyclic silaheterocycles, 6,6-dimethyl-2-aryl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3,5]thiazasilines, which could be developed as potential sila-drugs. The reactions of several 3-aryl-5-mercapto-1,2,4-triazoles with bis(chloromethyl)dimethylsilane under basic conditions gave high yields of bicyclic products. Reaction, product workup and isolation were streamlined without requiring an anhydrous solvent, inert gas or chromatographic purification. The products were structurally characterized by single-crystal X-ray diffraction.
KW - Cyclization
KW - Nitrogen heterocycles
KW - Silaheterocycle
KW - Silicon
KW - Triazole
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U2 - 10.1002/slct.201700273
DO - 10.1002/slct.201700273
M3 - Article
AN - SCOPUS:85041498842
SN - 2365-6549
VL - 2
SP - 3673
EP - 3675
JO - ChemistrySelect
JF - ChemistrySelect
IS - 13
ER -