Synthesis and Characterization of a New Class of Triazoles Containing Bicyclic Silaheterocycles

Tengjiao Wang; Hyeon Mo Cho; Myong Euy Lee

doi:10.1002/slct.201700273

Synthesis and Characterization of a New Class of Triazoles Containing Bicyclic Silaheterocycles

Tengjiao Wang, Hyeon Mo Cho, Myong Euy Lee

University College

Research output: Contribution to journal › Article › peer-review

Abstract

A new class of bicyclic silaheterocycles, 6,6-dimethyl-2-aryl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3,5]thiazasilines, which could be developed as potential sila-drugs. The reactions of several 3-aryl-5-mercapto-1,2,4-triazoles with bis(chloromethyl)dimethylsilane under basic conditions gave high yields of bicyclic products. Reaction, product workup and isolation were streamlined without requiring an anhydrous solvent, inert gas or chromatographic purification. The products were structurally characterized by single-crystal X-ray diffraction.

Original language	English
Pages (from-to)	3673-3675
Number of pages	3
Journal	ChemistrySelect
Volume	2
Issue number	13
DOIs	https://doi.org/10.1002/slct.201700273
Publication status	Published - 2017 May 2

Bibliographical note

Funding Information:
This research was partially supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2016R1D1 A1 A02937281). Mr. Wang also thanks Yonsei University for the outstanding foreign student scholarship. We thank Professor Moon-Gun Choi and Philjae Kang for their contributions to the crystal structures.

Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1002/slct.201700273

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title = "Synthesis and Characterization of a New Class of Triazoles Containing Bicyclic Silaheterocycles",

abstract = "A new class of bicyclic silaheterocycles, 6,6-dimethyl-2-aryl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3,5]thiazasilines, which could be developed as potential sila-drugs. The reactions of several 3-aryl-5-mercapto-1,2,4-triazoles with bis(chloromethyl)dimethylsilane under basic conditions gave high yields of bicyclic products. Reaction, product workup and isolation were streamlined without requiring an anhydrous solvent, inert gas or chromatographic purification. The products were structurally characterized by single-crystal X-ray diffraction.",

author = "Tengjiao Wang and Cho, {Hyeon Mo} and Lee, {Myong Euy}",

note = "Funding Information: This research was partially supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2016R1D1 A1 A02937281). Mr. Wang also thanks Yonsei University for the outstanding foreign student scholarship. We thank Professor Moon-Gun Choi and Philjae Kang for their contributions to the crystal structures. Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2017",

month = may,

day = "2",

doi = "10.1002/slct.201700273",

language = "English",

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journal = "ChemistrySelect",

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AU - Wang, Tengjiao

AU - Cho, Hyeon Mo

AU - Lee, Myong Euy

N1 - Funding Information: This research was partially supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2016R1D1 A1 A02937281). Mr. Wang also thanks Yonsei University for the outstanding foreign student scholarship. We thank Professor Moon-Gun Choi and Philjae Kang for their contributions to the crystal structures. Publisher Copyright: © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2017/5/2

Y1 - 2017/5/2

N2 - A new class of bicyclic silaheterocycles, 6,6-dimethyl-2-aryl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3,5]thiazasilines, which could be developed as potential sila-drugs. The reactions of several 3-aryl-5-mercapto-1,2,4-triazoles with bis(chloromethyl)dimethylsilane under basic conditions gave high yields of bicyclic products. Reaction, product workup and isolation were streamlined without requiring an anhydrous solvent, inert gas or chromatographic purification. The products were structurally characterized by single-crystal X-ray diffraction.

AB - A new class of bicyclic silaheterocycles, 6,6-dimethyl-2-aryl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3,5]thiazasilines, which could be developed as potential sila-drugs. The reactions of several 3-aryl-5-mercapto-1,2,4-triazoles with bis(chloromethyl)dimethylsilane under basic conditions gave high yields of bicyclic products. Reaction, product workup and isolation were streamlined without requiring an anhydrous solvent, inert gas or chromatographic purification. The products were structurally characterized by single-crystal X-ray diffraction.

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Synthesis and Characterization of a New Class of Triazoles Containing Bicyclic Silaheterocycles

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