Synthesis and Characterization of a New Class of Triazoles Containing Bicyclic Silaheterocycles

Tengjiao Wang, Hyeon Mo Cho, Myong Euy Lee

Research output: Contribution to journalArticlepeer-review


A new class of bicyclic silaheterocycles, 6,6-dimethyl-2-aryl-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3,5]thiazasilines, which could be developed as potential sila-drugs. The reactions of several 3-aryl-5-mercapto-1,2,4-triazoles with bis(chloromethyl)dimethylsilane under basic conditions gave high yields of bicyclic products. Reaction, product workup and isolation were streamlined without requiring an anhydrous solvent, inert gas or chromatographic purification. The products were structurally characterized by single-crystal X-ray diffraction.

Original languageEnglish
Pages (from-to)3673-3675
Number of pages3
Issue number13
Publication statusPublished - 2017 May 2

Bibliographical note

Funding Information:
This research was partially supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2016R1D1 A1 A02937281). Mr. Wang also thanks Yonsei University for the outstanding foreign student scholarship. We thank Professor Moon-Gun Choi and Philjae Kang for their contributions to the crystal structures.

Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

All Science Journal Classification (ASJC) codes

  • Chemistry(all)


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