Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part II

Jee Sun Yang; Doona Song; Won Jin Ko; Bunyea Kim; Bo Kyung Kim; Song Kyu Park; Misun Won; Kiho Lee; Kyeong Lee; Hwan Mook Kim; Gyoonhee Han

doi:10.1016/j.ejmech.2012.12.063

Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part II

Jee Sun Yang, Doona Song, Won Jin Ko, Bunyea Kim, Bo Kyung Kim, Song Kyu Park, Misun Won, Kiho Lee, Kyeong Lee, Hwan Mook Kim, Gyoonhee Han

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N,N-diethyl-N-(2-(N-methyltetradecanamido)ethyl)prop-2-en-1-aminium bromide (3b) exhibited potent pro-apoptotic activity, through RhoB activation, in HeLa cells.

Original language	English
Pages (from-to)	621-628
Number of pages	8
Journal	European Journal of Medicinal Chemistry
Volume	63
DOIs	https://doi.org/10.1016/j.ejmech.2012.12.063
Publication status	Published - 2013

Bibliographical note

Funding Information:
This research was supported by National Research Foundation ( 2012-0000884 ); Korean Research WCU grant ( R31-2008-000-10086-0 ); and the Brain Korea 21 Project of the Republic of Korea .

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejmech.2012.12.063

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title = "Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part II",

abstract = "A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N,N-diethyl-N-(2-(N-methyltetradecanamido)ethyl)prop-2-en-1-aminium bromide (3b) exhibited potent pro-apoptotic activity, through RhoB activation, in HeLa cells.",

author = "Yang, {Jee Sun} and Doona Song and Ko, {Won Jin} and Bunyea Kim and Kim, {Bo Kyung} and Park, {Song Kyu} and Misun Won and Kiho Lee and Kyeong Lee and Kim, {Hwan Mook} and Gyoonhee Han",

note = "Funding Information: This research was supported by National Research Foundation ( 2012-0000884 ); Korean Research WCU grant ( R31-2008-000-10086-0 ); and the Brain Korea 21 Project of the Republic of Korea . ",

year = "2013",

doi = "10.1016/j.ejmech.2012.12.063",

language = "English",

volume = "63",

pages = "621--628",

journal = "European Journal of Medicinal Chemistry",

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T1 - Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy

T2 - Part II

AU - Yang, Jee Sun

AU - Song, Doona

AU - Ko, Won Jin

AU - Kim, Bunyea

AU - Kim, Bo Kyung

AU - Park, Song Kyu

AU - Won, Misun

AU - Lee, Kiho

AU - Lee, Kyeong

AU - Kim, Hwan Mook

AU - Han, Gyoonhee

N1 - Funding Information: This research was supported by National Research Foundation ( 2012-0000884 ); Korean Research WCU grant ( R31-2008-000-10086-0 ); and the Brain Korea 21 Project of the Republic of Korea .

PY - 2013

Y1 - 2013

N2 - A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N,N-diethyl-N-(2-(N-methyltetradecanamido)ethyl)prop-2-en-1-aminium bromide (3b) exhibited potent pro-apoptotic activity, through RhoB activation, in HeLa cells.

AB - A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N,N-diethyl-N-(2-(N-methyltetradecanamido)ethyl)prop-2-en-1-aminium bromide (3b) exhibited potent pro-apoptotic activity, through RhoB activation, in HeLa cells.

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SN - 0223-5234

VL - 63

SP - 621

EP - 628

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

ER -

Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part II

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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