Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues

Yun Bong Kim, Yong Hae Kim, Ju Youn Park, Soo Kie Kim

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282 Citations (Scopus)


Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between -S-S- bond. The compound 1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5-8 μg/mL. According to the eukaryotic or prokaryotic data, 1a might be a first analogue to replace echinomycin.

Original languageEnglish
Pages (from-to)541-544
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number2
Publication statusPublished - 2004 Jan

Bibliographical note

Funding Information:
This work was supported by Grant No. R02-2002-000-00097-0 from Korea Science & Engineering Foundation.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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