Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues

Yun Bong Kim; Yong Hae Kim; Ju Youn Park; Soo Kie Kim

doi:10.1016/j.bmcl.2003.09.086

Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues

Yun Bong Kim, Yong Hae Kim, Ju Youn Park, Soo Kie Kim

Microbiology

Research output: Contribution to journal › Article › peer-review

282 Citations (Scopus)

Abstract

Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between -S-S- bond. The compound 1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5-8 μg/mL. According to the eukaryotic or prokaryotic data, 1a might be a first analogue to replace echinomycin.

Original language	English
Pages (from-to)	541-544
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2003.09.086
Publication status	Published - 2004 Jan

Bibliographical note

Funding Information:
This work was supported by Grant No. R02-2002-000-00097-0 from Korea Science & Engineering Foundation.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2003.09.086

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title = "Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues",

abstract = "Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between -S-S- bond. The compound 1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5-8 μg/mL. According to the eukaryotic or prokaryotic data, 1a might be a first analogue to replace echinomycin.",

author = "Kim, {Yun Bong} and Kim, {Yong Hae} and Park, {Ju Youn} and Kim, {Soo Kie}",

note = "Funding Information: This work was supported by Grant No. R02-2002-000-00097-0 from Korea Science & Engineering Foundation.",

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AU - Park, Ju Youn

AU - Kim, Soo Kie

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Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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