Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents

Sun Young Jang; Young Hwan Ha; Seung Whan Ko; Wonku Lee; Jongkook Lee; Sunghoon Kim; Yong Woo Kim; Won Koo Lee; Hyun Joon Ha

doi:10.1016/j.bmcl.2004.05.066

Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents

Sun Young Jang, Young Hwan Ha, Seung Whan Ko, Wonku Lee, Jongkook Lee, Sunghoon Kim, Yong Woo Kim, Won Koo Lee, Hyun Joon Ha

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A series of 4-arylpiperazin-1-yl-3-phenyloxazolidin-2-one derivatives with diversification of the N-substituents such as methylene O-linked heterocycles, thioamide, dithiocarbamate, thiourea, and thiocarbamate were synthesized and evaluated as antibacterial agents. Their in vitro activities (MIC) were evaluated against MRSA and VRE resistant Gram-positive strains such as Staphylococcus and Enterococcus. Most of the compounds were more potent in vitro but less active in vivo than linezolid.

Original language	English
Pages (from-to)	3881-3883
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2004.05.066
Publication status	Published - 2004 Aug 2

Bibliographical note

Funding Information:
The financial support from the Center for Bioactive Molecular Hybrids is gratefully acknowledged.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2004.05.066

Cite this

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title = "Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents",

abstract = "A series of 4-arylpiperazin-1-yl-3-phenyloxazolidin-2-one derivatives with diversification of the N-substituents such as methylene O-linked heterocycles, thioamide, dithiocarbamate, thiourea, and thiocarbamate were synthesized and evaluated as antibacterial agents. Their in vitro activities (MIC) were evaluated against MRSA and VRE resistant Gram-positive strains such as Staphylococcus and Enterococcus. Most of the compounds were more potent in vitro but less active in vivo than linezolid.",

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note = "Funding Information: The financial support from the Center for Bioactive Molecular Hybrids is gratefully acknowledged.",

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doi = "10.1016/j.bmcl.2004.05.066",

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AU - Jang, Sun Young

AU - Ha, Young Hwan

AU - Ko, Seung Whan

AU - Lee, Wonku

AU - Lee, Jongkook

AU - Kim, Sunghoon

AU - Kim, Yong Woo

AU - Lee, Won Koo

AU - Ha, Hyun Joon

N1 - Funding Information: The financial support from the Center for Bioactive Molecular Hybrids is gratefully acknowledged.

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AB - A series of 4-arylpiperazin-1-yl-3-phenyloxazolidin-2-one derivatives with diversification of the N-substituents such as methylene O-linked heterocycles, thioamide, dithiocarbamate, thiourea, and thiocarbamate were synthesized and evaluated as antibacterial agents. Their in vitro activities (MIC) were evaluated against MRSA and VRE resistant Gram-positive strains such as Staphylococcus and Enterococcus. Most of the compounds were more potent in vitro but less active in vivo than linezolid.

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Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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