Syndecan-2 functions as a docking receptor for pro-matrix metalloproteinase-7 in human colon cancer cells

Heui Young Ryu, Jiseon Lee, Sanghwa Yang, Haein Park, Sojoong Choi, Kyeong Cheon Jung, Seung Taek Lee, Je Kyung Seong, Inn Oc Han, Eok Soo Oh

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


Although elevated syndecan-2 expression is known to be crucial for the tumorigenic activity in colon carcinoma cells, how syndecan-2 regulates colon cancer is unclear. In human colon adenocarcinoma tissue samples, we found that both mRNA and protein expression of syndecan-2 were increased, compared with the neighboring normal epithelium, suggesting that syndecan-2 plays functional roles in human colon cancer cells. Consistent with this notion, syndecan-2-overexpressing HT-29 colon adenocarcinoma cells showed enhanced migration/invasion, anchorage-independent growth, and primary tumor formation in nude mice, paralleling their morphological changes into highly tumorigenic cells. In addition, our experiments revealed that syndecan-2 enhanced both expression and secretion of matrix metalloproteinase-7 (MMP-7), directly interacted with pro-MMP-7, and potentiated the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Collectively, these data strongly suggest that syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells.

Original languageEnglish
Pages (from-to)35692-35701
Number of pages10
JournalJournal of Biological Chemistry
Issue number51
Publication statusPublished - 2009 Dec 18

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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