Synchronous primary gastric mantle cell lymphoma and early gastric carcinoma: A case report

Yosep Chong, John Junghun Shin, Mee Yon Cho, Ying Cui, Ho Young Kim, Kwang Hwa Park

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Mantle cell lymphoma (MCL) commonly invades the gastrointestinal (GI) tract. However, primary GI MCL is rare. We experienced a case of synchronous early gastric cancer (EGC) with primary gastric MCL found as a single early lesion rather than as multiple lymphomatous polyposis. An EGC was found in the cardia of a 64-year-old male on a routine GI endoscopic examination. A specimen obtained by total gastrectomy revealed another slightly elevated lesion in the pylorus. Microscopically, monotonous small- to medium-sized atypical lymphocytes with angulated nuclei formed a mass beneath the gastric mucosa. On immunohistochemical staining, the tumor cells revealed strong positivity for cyclin D1, positivity for both CD20 and bcl-2, and weak positivity for CD5, suggesting MCL. Clinically, there was no lymphoma in any other part of the body. This is the first case of an EGC accompanying a primary gastric MCL. Further investigation of a relationship between MCL and EGC and of factors that may affect GI involvement of MCL is necessary.

Original languageEnglish
Pages (from-to)407-411
Number of pages5
JournalPathology Research and Practice
Issue number6
Publication statusPublished - 2008 Jun 2

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology


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