Swarming Magnetic Photoactive Microrobots for Dental Implant Biofilm Eradication

Carmen C. Mayorga-Martinez; Jaroslav Zelenka; Karel Klima; Paula Mayorga-Burrezo; Lan Hoang; Tomas Ruml; Martin Pumera

doi:10.1021/acsnano.2c02516

Swarming Magnetic Photoactive Microrobots for Dental Implant Biofilm Eradication

Carmen C. Mayorga-Martinez, Jaroslav Zelenka, Karel Klima, Paula Mayorga-Burrezo, Lan Hoang, Tomas Ruml, Martin Pumera

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Titanium dental implants are a multibillion dollar market in the United States alone. The growth of a bacterial biofilm on a dental implant can cause gingivitis, implant loss, and expensive subsequent care. Herein, we demonstrate the efficient eradication of dental biofilm on titanium dental implants via swarming magnetic microrobots based on ferromagnetic (Fe₃O₄) and photoactive (BiVO₄) materials through polyethylenimine micelles. The ferromagnetic component serves as a propulsion force using a transversal rotating magnetic field while BiVO₄is the photoactive generator of reactive oxygen species to eradicate the biofilm colonies. Such photoactive magnetically powered, precisely navigated microrobots are able to destroy biofilm colonies on titanium implants, demonstrating their use in precision medicine.

Original language	English
Pages (from-to)	8694-8703
Number of pages	10
Journal	ACS Nano
Volume	16
Issue number	6
DOIs	https://doi.org/10.1021/acsnano.2c02516
Publication status	Published - 2022 Jun 28

Bibliographical note

Funding Information:
This work was supported by the project “Advanced Functional Nanorobots” (reg. no. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR), the Ministry of Health of the Czech Republic (NU21-08-00407), and Ministry of Education, Youth and Sports (Czech Republic) grant LL2002 under ERC CZ program. We thank MIS (MIS Implants Technologies Ltd., Israel) for donating dental implants. We did not receive any other support from MIS.

Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.

All Science Journal Classification (ASJC) codes

Materials Science(all)
Engineering(all)
Physics and Astronomy(all)

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10.1021/acsnano.2c02516

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title = "Swarming Magnetic Photoactive Microrobots for Dental Implant Biofilm Eradication",

abstract = "Titanium dental implants are a multibillion dollar market in the United States alone. The growth of a bacterial biofilm on a dental implant can cause gingivitis, implant loss, and expensive subsequent care. Herein, we demonstrate the efficient eradication of dental biofilm on titanium dental implants via swarming magnetic microrobots based on ferromagnetic (Fe3O4) and photoactive (BiVO4) materials through polyethylenimine micelles. The ferromagnetic component serves as a propulsion force using a transversal rotating magnetic field while BiVO4is the photoactive generator of reactive oxygen species to eradicate the biofilm colonies. Such photoactive magnetically powered, precisely navigated microrobots are able to destroy biofilm colonies on titanium implants, demonstrating their use in precision medicine.",

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AU - Hoang, Lan

AU - Ruml, Tomas

AU - Pumera, Martin

N1 - Funding Information: This work was supported by the project “Advanced Functional Nanorobots” (reg. no. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR), the Ministry of Health of the Czech Republic (NU21-08-00407), and Ministry of Education, Youth and Sports (Czech Republic) grant LL2002 under ERC CZ program. We thank MIS (MIS Implants Technologies Ltd., Israel) for donating dental implants. We did not receive any other support from MIS. Publisher Copyright: © 2022 American Chemical Society. All rights reserved.

PY - 2022/6/28

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N2 - Titanium dental implants are a multibillion dollar market in the United States alone. The growth of a bacterial biofilm on a dental implant can cause gingivitis, implant loss, and expensive subsequent care. Herein, we demonstrate the efficient eradication of dental biofilm on titanium dental implants via swarming magnetic microrobots based on ferromagnetic (Fe3O4) and photoactive (BiVO4) materials through polyethylenimine micelles. The ferromagnetic component serves as a propulsion force using a transversal rotating magnetic field while BiVO4is the photoactive generator of reactive oxygen species to eradicate the biofilm colonies. Such photoactive magnetically powered, precisely navigated microrobots are able to destroy biofilm colonies on titanium implants, demonstrating their use in precision medicine.

AB - Titanium dental implants are a multibillion dollar market in the United States alone. The growth of a bacterial biofilm on a dental implant can cause gingivitis, implant loss, and expensive subsequent care. Herein, we demonstrate the efficient eradication of dental biofilm on titanium dental implants via swarming magnetic microrobots based on ferromagnetic (Fe3O4) and photoactive (BiVO4) materials through polyethylenimine micelles. The ferromagnetic component serves as a propulsion force using a transversal rotating magnetic field while BiVO4is the photoactive generator of reactive oxygen species to eradicate the biofilm colonies. Such photoactive magnetically powered, precisely navigated microrobots are able to destroy biofilm colonies on titanium implants, demonstrating their use in precision medicine.

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Swarming Magnetic Photoactive Microrobots for Dental Implant Biofilm Eradication

Abstract

Bibliographical note

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