Surgical management of extra-regional lymph node metastasis in colorectal cancer

Mahdi H. Albandar, Min Soo Cho, Sung Uk Bae, Nam Kyu Kim

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)


ABSTRACT: One of the major problems in rectal cancer surgery is local recurrence, found in an average of 21% to 46% cases in 1990. However, the advent of chemo-radiotherapy (CRT) and total mesorectal excision (TME) improve local control and enhances survival rates in colorectal cancer (CRC). Regional lymph node involvement is determined to be an independent prognostic factor in local recurrence; however, extra-regional lymph node (ERLN) metastasis has a higher recurrence rate (up to 58.1%). Lack of supportive data in management of ERLN metastasis in CRC has added further strain and challenges to structure a unique treatment strategy. ERLN refers to extra-mesenteric involvement either in the para-aortic lymph node (PALN) or the lateral pelvic lymph node (LPLN). Treatment of ERLN metastasis is challenging because of the shortage of the resources. Here, we will outline and summarize approaches and management of ERLN metastasis.

Original languageEnglish
Pages (from-to)503-513
Number of pages11
JournalExpert Review of Anticancer Therapy
Issue number5
Publication statusPublished - 2016 May 3

Bibliographical note

Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology (medical)


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