Surface-modified magnetite nanoparticles for hyperthermia: Preparation, characterization, and cytotoxicity studies

D. H. Kim, S. H. Lee, K. H. Im, K. N. Kim, K. M. Kim, I. B. Shim, M. H. Lee, Y. K. Lee

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91 Citations (Scopus)


Biocompatible magnetic nanoparticles could be selected for smart hyperthermia. The magnetic particles should have a narrow size distribution and surface modified with biocompatible materials. In this study, the effects of surface modification in nano-magnetite were evaluated by characterization and cell response. The synthesized magnetite exhibited a mean diameter of 10.3 ± 2.6 nm. The temperature change under alternating magnetic field and saturation magnetization (Ms) was ΔT = 23 °C, Ms = 25.6 emu/g and ΔT = 12 °C, Ms = 16.4 emu/g in chitosan and starch coated magnetite, respectively. In cytotoxic test, the viability of L929 cells was the greatest value 93.67% in chitosan coated magnetic particles. The exothermic and biocompatible chitosan coated magnetite will be selected for optimized hyperthermic thermoseed.

Original languageEnglish
Pages (from-to)e242-e246
JournalCurrent Applied Physics
Issue numberSUPPL. 1
Publication statusPublished - 2006 Aug

Bibliographical note

Funding Information:
This work was supported by Grant No. R13-2003-13 from the Medical Science and Engineering Research Program of the Korea Science & Engineering Foundation.

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Physics and Astronomy(all)


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