Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy

Woo Dong Jang; Nobuhiro Nishiyama; Guo Dong Zhang; Atsushi Harada; Dong Lin Jiang; Satoko Kawauchi; Yuji Morimoto; Makoto Kikuchi; Hiroyuki Koyama; Takuzo Aida; Kazunori Kataoka

doi:10.1002/anie.200461603

Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy

Woo Dong Jang, Nobuhiro Nishiyama, Guo Dong Zhang, Atsushi Harada, Dong Lin Jiang, Satoko Kawauchi, Yuji Morimoto, Makoto Kikuchi, Hiroyuki Koyama, Takuzo Aida, Kazunori Kataoka

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Photo finish: A polymeric micelle system is formed in aqueous media by electrostatic assembly of an anionic dendrimeric porphyrin and a poly(ethylene glycol)poly(L-lysine) block copolymer (see picture). The micelles exhibit high photocytotoxicity and stability. The hydrodynamic size (ca. 60 nim) makes this polymeric micelle system suitable for intravenous administration in photodynamic tumor therapy. (Figure Presented).

Original language	English
Pages (from-to)	419-423
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	3
DOIs	https://doi.org/10.1002/anie.200461603
Publication status	Published - 2005 Jan 3

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

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10.1002/anie.200461603

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Jang, W. D., Nishiyama, N., Zhang, G. D., Harada, A., Jiang, D. L., Kawauchi, S., Morimoto, Y., Kikuchi, M., Koyama, H., Aida, T., & Kataoka, K. (2005). Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy. Angewandte Chemie - International Edition, 44(3), 419-423. https://doi.org/10.1002/anie.200461603

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title = "Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy",

abstract = "Photo finish: A polymeric micelle system is formed in aqueous media by electrostatic assembly of an anionic dendrimeric porphyrin and a poly(ethylene glycol)poly(L-lysine) block copolymer (see picture). The micelles exhibit high photocytotoxicity and stability. The hydrodynamic size (ca. 60 nim) makes this polymeric micelle system suitable for intravenous administration in photodynamic tumor therapy. (Figure Presented).",

author = "Jang, {Woo Dong} and Nobuhiro Nishiyama and Zhang, {Guo Dong} and Atsushi Harada and Jiang, {Dong Lin} and Satoko Kawauchi and Yuji Morimoto and Makoto Kikuchi and Hiroyuki Koyama and Takuzo Aida and Kazunori Kataoka",

year = "2005",

month = jan,

day = "3",

doi = "10.1002/anie.200461603",

language = "English",

volume = "44",

pages = "419--423",

journal = "Angewandte Chemie - International Edition",

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Jang, WD, Nishiyama, N, Zhang, GD, Harada, A, Jiang, DL, Kawauchi, S, Morimoto, Y, Kikuchi, M, Koyama, H, Aida, T & Kataoka, K 2005, 'Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy', Angewandte Chemie - International Edition, vol. 44, no. 3, pp. 419-423. https://doi.org/10.1002/anie.200461603

Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy. / Jang, Woo Dong; Nishiyama, Nobuhiro; Zhang, Guo Dong et al.
In: Angewandte Chemie - International Edition, Vol. 44, No. 3, 03.01.2005, p. 419-423.

Research output: Contribution to journal › Article › peer-review

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T1 - Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy

AU - Jang, Woo Dong

AU - Nishiyama, Nobuhiro

AU - Zhang, Guo Dong

AU - Harada, Atsushi

AU - Jiang, Dong Lin

AU - Kawauchi, Satoko

AU - Morimoto, Yuji

AU - Kikuchi, Makoto

AU - Koyama, Hiroyuki

AU - Aida, Takuzo

AU - Kataoka, Kazunori

PY - 2005/1/3

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N2 - Photo finish: A polymeric micelle system is formed in aqueous media by electrostatic assembly of an anionic dendrimeric porphyrin and a poly(ethylene glycol)poly(L-lysine) block copolymer (see picture). The micelles exhibit high photocytotoxicity and stability. The hydrodynamic size (ca. 60 nim) makes this polymeric micelle system suitable for intravenous administration in photodynamic tumor therapy. (Figure Presented).

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Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy

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