Supramolecular micelle from amphiphilic Mn(III)-porphyrin derivatives as a potential MRI contrast agent

Kwangmo Choi; Do Hyung Lee; Woo Dong Jang

doi:10.5012/bkcs.2010.31.03.639

Supramolecular micelle from amphiphilic Mn(III)-porphyrin derivatives as a potential MRI contrast agent

Kwangmo Choi, Do Hyung Lee, Woo Dong Jang

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Amphiphilic porphyrin derivatives have been synthesized and characterized by 1H NMR and MALDI-TOF-MS. All porphyrin derivatives showed very high solubility to aqueous medium as well as hydrophobic organic solvent. The UVvis absorption of the porphyrin derivatives showed significant broadness and decrease of maximum intensity of absorption in aqueous solution. SEM experiment showed the formation of spherical micellar structure. The T1 relaxation time of aqueous medium was drastically decreased in the presence of Mn(III)-porphyrin derivative, indicating that the supramolecular micelle has strong possibility to use as a T1 contrast agent.

Original language	English
Pages (from-to)	639-644
Number of pages	6
Journal	Bulletin of the Korean Chemical Society
Volume	31
Issue number	3
DOIs	https://doi.org/10.5012/bkcs.2010.31.03.639
Publication status	Published - 2010 Mar

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.5012/bkcs.2010.31.03.639

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AU - Choi, Kwangmo

AU - Lee, Do Hyung

AU - Jang, Woo Dong

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Y1 - 2010/3

N2 - Amphiphilic porphyrin derivatives have been synthesized and characterized by 1H NMR and MALDI-TOF-MS. All porphyrin derivatives showed very high solubility to aqueous medium as well as hydrophobic organic solvent. The UVvis absorption of the porphyrin derivatives showed significant broadness and decrease of maximum intensity of absorption in aqueous solution. SEM experiment showed the formation of spherical micellar structure. The T1 relaxation time of aqueous medium was drastically decreased in the presence of Mn(III)-porphyrin derivative, indicating that the supramolecular micelle has strong possibility to use as a T1 contrast agent.

AB - Amphiphilic porphyrin derivatives have been synthesized and characterized by 1H NMR and MALDI-TOF-MS. All porphyrin derivatives showed very high solubility to aqueous medium as well as hydrophobic organic solvent. The UVvis absorption of the porphyrin derivatives showed significant broadness and decrease of maximum intensity of absorption in aqueous solution. SEM experiment showed the formation of spherical micellar structure. The T1 relaxation time of aqueous medium was drastically decreased in the presence of Mn(III)-porphyrin derivative, indicating that the supramolecular micelle has strong possibility to use as a T1 contrast agent.

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JO - Bulletin of the Korean Chemical Society

JF - Bulletin of the Korean Chemical Society

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Supramolecular micelle from amphiphilic Mn(III)-porphyrin derivatives as a potential MRI contrast agent

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