Suppression of DRR1 results in the accumulation of insoluble ubiquitinated proteins, which impairs drought stress tolerance

Seong Gwan Yu; Na Hyun Cho; Jong Hum Kim; Tae Rin Oh; Woo Taek Kim

doi:10.1111/jipb.13014

Suppression of DRR1 results in the accumulation of insoluble ubiquitinated proteins, which impairs drought stress tolerance

Seong Gwan Yu, Na Hyun Cho, Jong Hum Kim, Tae Rin Oh, Woo Taek Kim

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Drought stress has detrimental effects on plants. Although the abscisic acid (ABA)-mediated drought response is well established, defensive mechanisms to cope with dehydration-induced proteotoxicity have been rarely studied. DRR1 was identified as an Arabidopsis drought-induced gene encoding an ER-localized RING-type E3 Ub ligase. Suppression of DRR1 markedly reduced tolerance to drought and proteotoxic stress without altering ABA-mediated germination and stomatal movement. Proteotoxicity- and dehydration-induced insoluble ubiquitinated protein accumulation was more obvious in DRR1 loss-of-function plants than in wild-type plants. These results suggest that DRR1 is involved in an ABA-independent drought stress response possibly through the mitigation of dehydration-induced proteotoxic stress.

Original language	English
Pages (from-to)	431-437
Number of pages	7
Journal	Journal of Integrative Plant Biology
Volume	63
Issue number	3
DOIs	https://doi.org/10.1111/jipb.13014
Publication status	Published - 2021 Mar

Bibliographical note

Funding Information:
This work was supported by grants from the National Research Foundation (Mid-Career Researcher Program 2020R1A2B5B02001590 and Basic Science Research Program 2018R1A6A1A03025607, Republic of Korea) to W.T.K. S.G.Y was the recipient of a Hyundai Motor Chung Mong-Koo Foundation Scholarship.

Funding Information:
This work was supported by grants from the National Research Foundation (Mid‐Career Researcher Program 2020R1A2B5B02001590 and Basic Science Research Program 2018R1A6A1A03025607, Republic of Korea) to W.T.K. S.G.Y was the recipient of a Hyundai Motor Chung Mong‐Koo Foundation Scholarship.

Publisher Copyright:
© 2020 Institute of Botany, Chinese Academy of Sciences

All Science Journal Classification (ASJC) codes

Biochemistry
Biochemistry, Genetics and Molecular Biology(all)
Plant Science

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10.1111/jipb.13014

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abstract = "Drought stress has detrimental effects on plants. Although the abscisic acid (ABA)-mediated drought response is well established, defensive mechanisms to cope with dehydration-induced proteotoxicity have been rarely studied. DRR1 was identified as an Arabidopsis drought-induced gene encoding an ER-localized RING-type E3 Ub ligase. Suppression of DRR1 markedly reduced tolerance to drought and proteotoxic stress without altering ABA-mediated germination and stomatal movement. Proteotoxicity- and dehydration-induced insoluble ubiquitinated protein accumulation was more obvious in DRR1 loss-of-function plants than in wild-type plants. These results suggest that DRR1 is involved in an ABA-independent drought stress response possibly through the mitigation of dehydration-induced proteotoxic stress.",

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AU - Oh, Tae Rin

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Suppression of DRR1 results in the accumulation of insoluble ubiquitinated proteins, which impairs drought stress tolerance

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