Suppression of cholangiocarcinoma development by aminoguanidine in the liver fluke-infested hamster

Ki Taek Nam; Dae Yong Kim; Mi Sun Park; Dong Deuk Jang; Ki Hwa Yang; Jeong Hee Han; Byung Il Yoon

doi:10.1293/tox.18.65

Suppression of cholangiocarcinoma development by aminoguanidine in the liver fluke-infested hamster

Ki Taek Nam, Dae Yong Kim, Mi Sun Park, Dong Deuk Jang, Ki Hwa Yang, Jeong Hee Han, Byung Il Yoon

BioMedical Science Institute

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Clonorchis sinensis (CS) infection combined with hepatocarcinogen treatment results in marked cholangiocarcinoma (CC) formation in hamsters. Hamsters were kept for 16 weeks with or without 1% aminoguanidine (AG) exposure through drinking water, and were treated with dimethylnitrosamine for 4 weeks, 2 days after being infected orally with 15 metacercariae of CS. Interestingly, of the 11 hamsters not treated with AG, 9 had malignant tumors, 1 had a benign tumor, and 1 was normal; however, of the 10 hamsters treated with AG, 5 had benign tumors, 4 had malignant tumors, and 1 was normal. Based on this result, AG has an inhibitory effect on the progression of CC. Further mechanistic study into the result of this morphological study is warranted. 2005

Original language	English
Pages (from-to)	65-68
Number of pages	4
Journal	Journal of Toxicologic Pathology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1293/tox.18.65
Publication status	Published - 2005

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Toxicology

Access to Document

10.1293/tox.18.65

Cite this

@article{4ff28727d6c54b7a86458880de02c256,

title = "Suppression of cholangiocarcinoma development by aminoguanidine in the liver fluke-infested hamster",

abstract = "Clonorchis sinensis (CS) infection combined with hepatocarcinogen treatment results in marked cholangiocarcinoma (CC) formation in hamsters. Hamsters were kept for 16 weeks with or without 1% aminoguanidine (AG) exposure through drinking water, and were treated with dimethylnitrosamine for 4 weeks, 2 days after being infected orally with 15 metacercariae of CS. Interestingly, of the 11 hamsters not treated with AG, 9 had malignant tumors, 1 had a benign tumor, and 1 was normal; however, of the 10 hamsters treated with AG, 5 had benign tumors, 4 had malignant tumors, and 1 was normal. Based on this result, AG has an inhibitory effect on the progression of CC. Further mechanistic study into the result of this morphological study is warranted. 2005",

author = "Nam, {Ki Taek} and Kim, {Dae Yong} and Park, {Mi Sun} and Jang, {Dong Deuk} and Yang, {Ki Hwa} and Han, {Jeong Hee} and Yoon, {Byung Il}",

year = "2005",

doi = "10.1293/tox.18.65",

language = "English",

volume = "18",

pages = "65--68",

journal = "Journal of Toxicologic Pathology",

issn = "0914-9198",

publisher = "Japanese Society of Toxicologic Pathology",

number = "1",

}

TY - JOUR

T1 - Suppression of cholangiocarcinoma development by aminoguanidine in the liver fluke-infested hamster

AU - Nam, Ki Taek

AU - Kim, Dae Yong

AU - Park, Mi Sun

AU - Jang, Dong Deuk

AU - Yang, Ki Hwa

AU - Han, Jeong Hee

AU - Yoon, Byung Il

PY - 2005

Y1 - 2005

N2 - Clonorchis sinensis (CS) infection combined with hepatocarcinogen treatment results in marked cholangiocarcinoma (CC) formation in hamsters. Hamsters were kept for 16 weeks with or without 1% aminoguanidine (AG) exposure through drinking water, and were treated with dimethylnitrosamine for 4 weeks, 2 days after being infected orally with 15 metacercariae of CS. Interestingly, of the 11 hamsters not treated with AG, 9 had malignant tumors, 1 had a benign tumor, and 1 was normal; however, of the 10 hamsters treated with AG, 5 had benign tumors, 4 had malignant tumors, and 1 was normal. Based on this result, AG has an inhibitory effect on the progression of CC. Further mechanistic study into the result of this morphological study is warranted. 2005

AB - Clonorchis sinensis (CS) infection combined with hepatocarcinogen treatment results in marked cholangiocarcinoma (CC) formation in hamsters. Hamsters were kept for 16 weeks with or without 1% aminoguanidine (AG) exposure through drinking water, and were treated with dimethylnitrosamine for 4 weeks, 2 days after being infected orally with 15 metacercariae of CS. Interestingly, of the 11 hamsters not treated with AG, 9 had malignant tumors, 1 had a benign tumor, and 1 was normal; however, of the 10 hamsters treated with AG, 5 had benign tumors, 4 had malignant tumors, and 1 was normal. Based on this result, AG has an inhibitory effect on the progression of CC. Further mechanistic study into the result of this morphological study is warranted. 2005

UR - http://www.scopus.com/inward/record.url?scp=27444447100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27444447100&partnerID=8YFLogxK

U2 - 10.1293/tox.18.65

DO - 10.1293/tox.18.65

M3 - Article

AN - SCOPUS:27444447100

SN - 0914-9198

VL - 18

SP - 65

EP - 68

JO - Journal of Toxicologic Pathology

JF - Journal of Toxicologic Pathology

IS - 1

ER -

Suppression of cholangiocarcinoma development by aminoguanidine in the liver fluke-infested hamster

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this