[18F]FPEB and [18F]FDEGPECO comparative study of mGlu5 quantification in rodent brain

Jee Hae Kang; Minkyung Lee; Young Hoon Ryu; Chul Hyoung Lyoo; Chul Hoon Kim; Kyo Chul Lee; Tae Hyun Choi; Jae Yong Choi

doi:10.1016/j.apradiso.2015.01.025

[¹⁸F]FPEB and [¹⁸F]FDEGPECO comparative study of mGlu5 quantification in rodent brain

Jee Hae Kang, Minkyung Lee, Young Hoon Ryu, Chul Hyoung Lyoo, Chul Hoon Kim, Kyo Chul Lee, Tae Hyun Choi, Jae Yong Choi

Department of Neurology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The aim of this study is to compare [¹⁸F]FPEB and [¹⁸F]FDEGPECO for the quantification of mGlu5 receptors in rodent brains. After preparation of radioligands, dynamic PET data was acquired for 90min. Estimated non-displaceable binding potential (BP_ND) values were calculated from the non-invasive Logan's graphical analysis method. Although both radioligands showed similar radiochemical amenability, [¹⁸F]FPEB PET showed higher brain uptake and superior binding potential values than those of [¹⁸F]FDEGPECO PET (peak brain uptakes in the hippocampus and the striatum: 7.2-8.7 vs. 5.0-6.2, BP_ND: 7.3-9.6 vs. 0.3-0.4 for [¹⁸F]FPEB and [¹⁸F]FDEGPECO, respectively). In addition, the target-to-reference ratios for [¹⁸F]FPEB is >4 fold than those of [¹⁸F]FDEGPECO. From this evidence, we conclude that [¹⁸F]FPEB is a superior radioligand for mGlu5 imaging in preclinical studies.

Original language	English
Pages (from-to)	103-107
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	98
DOIs	https://doi.org/10.1016/j.apradiso.2015.01.025
Publication status	Published - 2015 Apr 1

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd.

All Science Journal Classification (ASJC) codes

Radiation

Access to Document

10.1016/j.apradiso.2015.01.025

Cite this

@article{8bd6aad231564ddfab1408cafa3c1412,

title = "[18F]FPEB and [18F]FDEGPECO comparative study of mGlu5 quantification in rodent brain",

abstract = "The aim of this study is to compare [18F]FPEB and [18F]FDEGPECO for the quantification of mGlu5 receptors in rodent brains. After preparation of radioligands, dynamic PET data was acquired for 90min. Estimated non-displaceable binding potential (BPND) values were calculated from the non-invasive Logan's graphical analysis method. Although both radioligands showed similar radiochemical amenability, [18F]FPEB PET showed higher brain uptake and superior binding potential values than those of [18F]FDEGPECO PET (peak brain uptakes in the hippocampus and the striatum: 7.2-8.7 vs. 5.0-6.2, BPND: 7.3-9.6 vs. 0.3-0.4 for [18F]FPEB and [18F]FDEGPECO, respectively). In addition, the target-to-reference ratios for [18F]FPEB is >4 fold than those of [18F]FDEGPECO. From this evidence, we conclude that [18F]FPEB is a superior radioligand for mGlu5 imaging in preclinical studies.",

author = "{Hae Kang}, Jee and Minkyung Lee and {Hoon Ryu}, Young and {Hyoung Lyoo}, Chul and {Hoon Kim}, Chul and {Chul Lee}, Kyo and {Hyun Choi}, Tae and {Yong Choi}, Jae",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = apr,

day = "1",

doi = "10.1016/j.apradiso.2015.01.025",

language = "English",

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T1 - [18F]FPEB and [18F]FDEGPECO comparative study of mGlu5 quantification in rodent brain

AU - Hae Kang, Jee

AU - Lee, Minkyung

AU - Hoon Ryu, Young

AU - Hyoung Lyoo, Chul

AU - Hoon Kim, Chul

AU - Chul Lee, Kyo

AU - Hyun Choi, Tae

AU - Yong Choi, Jae

PY - 2015/4/1

Y1 - 2015/4/1

N2 - The aim of this study is to compare [18F]FPEB and [18F]FDEGPECO for the quantification of mGlu5 receptors in rodent brains. After preparation of radioligands, dynamic PET data was acquired for 90min. Estimated non-displaceable binding potential (BPND) values were calculated from the non-invasive Logan's graphical analysis method. Although both radioligands showed similar radiochemical amenability, [18F]FPEB PET showed higher brain uptake and superior binding potential values than those of [18F]FDEGPECO PET (peak brain uptakes in the hippocampus and the striatum: 7.2-8.7 vs. 5.0-6.2, BPND: 7.3-9.6 vs. 0.3-0.4 for [18F]FPEB and [18F]FDEGPECO, respectively). In addition, the target-to-reference ratios for [18F]FPEB is >4 fold than those of [18F]FDEGPECO. From this evidence, we conclude that [18F]FPEB is a superior radioligand for mGlu5 imaging in preclinical studies.

AB - The aim of this study is to compare [18F]FPEB and [18F]FDEGPECO for the quantification of mGlu5 receptors in rodent brains. After preparation of radioligands, dynamic PET data was acquired for 90min. Estimated non-displaceable binding potential (BPND) values were calculated from the non-invasive Logan's graphical analysis method. Although both radioligands showed similar radiochemical amenability, [18F]FPEB PET showed higher brain uptake and superior binding potential values than those of [18F]FDEGPECO PET (peak brain uptakes in the hippocampus and the striatum: 7.2-8.7 vs. 5.0-6.2, BPND: 7.3-9.6 vs. 0.3-0.4 for [18F]FPEB and [18F]FDEGPECO, respectively). In addition, the target-to-reference ratios for [18F]FPEB is >4 fold than those of [18F]FDEGPECO. From this evidence, we conclude that [18F]FPEB is a superior radioligand for mGlu5 imaging in preclinical studies.

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