TY - GEN
T1 - Subpixel resolving optofluidic microscope based on super resolution algorithm
AU - Zheng, Guoan
AU - Lee, Seung Ah
AU - Yang, Samuel
AU - Yang, Changhuei
PY - 2011
Y1 - 2011
N2 - We report the implementation of a fully on-chip, lensless, sub-pixel resolving optofluidic microscope (SROFM) based on the super resolution algorithm. The device utilizes microfluidic flow to deliver specimens directly across a complementary metal oxide semiconductor (CMOS) sensor to generate a sequence of low-resolution (LR) projection images, where resolution is limited by the sensor's pixel size. This image sequence is then processed with a pixel super-resolution algorithm to reconstruct a single high resolution (HR) image, where features beyond the Nyquist rate of the LR images are resolved. We demonstrate the device's capabilities by imaging red blood cell, microspheres, protist Euglena gracilis, and Entamoeba invadens cysts with sub-cellular resolution. We also demonstrate the capability of SROFM for malaria infected red blood cell diagnostics.
AB - We report the implementation of a fully on-chip, lensless, sub-pixel resolving optofluidic microscope (SROFM) based on the super resolution algorithm. The device utilizes microfluidic flow to deliver specimens directly across a complementary metal oxide semiconductor (CMOS) sensor to generate a sequence of low-resolution (LR) projection images, where resolution is limited by the sensor's pixel size. This image sequence is then processed with a pixel super-resolution algorithm to reconstruct a single high resolution (HR) image, where features beyond the Nyquist rate of the LR images are resolved. We demonstrate the device's capabilities by imaging red blood cell, microspheres, protist Euglena gracilis, and Entamoeba invadens cysts with sub-cellular resolution. We also demonstrate the capability of SROFM for malaria infected red blood cell diagnostics.
UR - http://www.scopus.com/inward/record.url?scp=80055055836&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80055055836&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2011.5872653
DO - 10.1109/ISBI.2011.5872653
M3 - Conference contribution
AN - SCOPUS:80055055836
SN - 9781424441280
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 1362
EP - 1365
BT - 2011 8th IEEE International Symposium on Biomedical Imaging
T2 - 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11
Y2 - 30 March 2011 through 2 April 2011
ER -
