Structures and functions of multi-tRNA synthetase complexes

Myung Hee Kim, Sunghoon Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)


Human body is a finely-tuned machine that requires homeostatic balance based on systemically controlled biological processes involving DNA replication, transcription, translation, and energy metabolism. Ubiquitously expressed aminoacyl-tRNA synthetases have been investigated for many decades, and they act as cross-over mediators of important biological processes. In particular, a cytoplasmic multi-tRNA synthetase complex (MSC) appears to be a central machinery controlling the complexity of biological systems. The structural integrity of MSC determined by the associated components is correlated with increasing biological complexity that links to system development in higher organisms. Although the role of the MSCs is still unclear, this chapter describes the current knowledge on MSC components that are associated with and regulate functions beyond their catalytic activities with focus on human MSC.

Original languageEnglish
Title of host publicationBiology of Aminoacyl-tRNA Synthetases
EditorsLluís Ribas de Pouplana, Laurie S. Kaguni
PublisherAcademic Press
Number of pages25
ISBN (Print)9780128202609
Publication statusPublished - 2020 Jan

Publication series

ISSN (Print)1874-6047

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Biochemistry
  • Molecular Biology


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