Stratified mucin producing intraepithelial lesion

Yoon Jin Cha, Myoung Ju Koh, Young Tae Kim, Nam Hoon Cho

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


We report a case of stratified mucin producing intraepithelial lesion (SMILE), associated with adenocarcinoma and human papillomavirus (HPV) 18 infection. A 54-year-old lady presented with vaginal bleeding for 2 months. A punchy biopsy in private clinic showed papillary neoplasm composed of stratified columnar epithelium showing intracytoplasmic mucin vacuole. Microscopic examination for following cone biopsy demonstrated adenocarcinoma along with SMILE, and HPV 18 was detected by DNA chip examination. After several immunohistochemical stainings, SMILE showed predominant glandular differentiation.

Original languageEnglish
Pages (from-to)72-75
Number of pages4
JournalBasic and Applied Pathology
Issue number3
Publication statusPublished - 2012 Sept

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine


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