Sternberg working memory performance following treatment with pramipexole in patients with moderate-to-severe restless legs syndrome

Ki Young Jung, Sung Min Kim, Jin Young Song, Byeong Uk Lee, Chany Lee, Sang Kun Lee, Yong Seo Koo, Yong Won Cho, Jeong Woo Choi, Kyung Hwan Kim

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Objectives: We recently reported that the P300 amplitude related to the Sternberg working memory (WM) task was significantly lower in drug-naïve severe restless legs syndrome (RLS) patients than controls. Here, we evaluated the effects of pramipexole on the Sternberg WM task performance by event-related potential (ERP) study. Methods: Thirteen drug-naïve RLS patients (52.0 ± 9.48 years) were enrolled in the study. Pramipexole was administered over a period of 12 weeks every night 1 h before bedtime. Two ERP studies were carried out: the first was performed just before giving the first dose of pramipexole and the second was conducted at 12-16 weeks after commencement of pramipexole administration. P300 amplitudes and reaction times were compared before and after treatment considering brain regions and memory load as within-subject factors. Clinical and sleep-related variables were correlated with P300 amplitude. Results: After treatment with pramipexole, the International RLS Severity Scale (IRLS) score was significantly decreased. Sleep quality and depression were also significantly improved. Omission error was significantly reduced without significant change of commission error. Reaction time was significantly shortened, regardless of memory load size, following treatment with pramipexole. Parietal P300 amplitude was significantly increased after treatment with pramipexole for all memory load sizes. Increase of frontal P300 amplitude was significantly correlated with improvement of sleep duration, IRLS, Insomnia Severity Index, and Pittsburgh Sleep Quality Index score. Conclusion: Our study suggested that pramipexole improves WM performance in patients with RLS in addition to improving RLS symptoms, sleep disturbance, and depression.

Original languageEnglish
Pages (from-to)703-708
Number of pages6
JournalSleep Medicine
Issue number6
Publication statusPublished - 2015 Jun 1

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (no. 20110029740 ) and by future environmental R&D grant funded by the Korea Environmental Industry and Technology Institute (No. RE201206020 ).

Publisher Copyright:
© 2014 Elsevier B.V.

All Science Journal Classification (ASJC) codes

  • Medicine(all)


Dive into the research topics of 'Sternberg working memory performance following treatment with pramipexole in patients with moderate-to-severe restless legs syndrome'. Together they form a unique fingerprint.

Cite this