Stereoselective synthesis of (+)-spectaline

Yiu Suk Lee, Yong Ho Shin, Yong Hyun Kim, Kee Young Lee, Chang Young Oh, Sung Jae Pyun, Hyun Ju Park, Jin Hyun Jeong, Won Hun Ham

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Our synthesis of (+)-spectaline revealed that the methodology involving diastereoselective palladium(0)-catalyzed oxazoline formation and intramolecular reductive amination by catalytic hydrogenation of an oxazoline is an effective method for the asymmetric synthesis of natural products possessing complex functionalized piperidine cores.

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalTetrahedron Asymmetry
Issue number1
Publication statusPublished - 2003 Jan 6

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (01-PJ1-PG1-01CH13-0002).

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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