Stereoselective synthesis of (+)-spectaline

Yiu Suk Lee; Yong Ho Shin; Yong Hyun Kim; Kee Young Lee; Chang Young Oh; Sung Jae Pyun; Hyun Ju Park; Jin Hyun Jeong; Won Hun Ham

doi:10.1016/S0957-4166(02)00794-2

Stereoselective synthesis of (+)-spectaline

Yiu Suk Lee, Yong Ho Shin, Yong Hyun Kim, Kee Young Lee, Chang Young Oh, Sung Jae Pyun, Hyun Ju Park, Jin Hyun Jeong, Won Hun Ham

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Our synthesis of (+)-spectaline revealed that the methodology involving diastereoselective palladium(0)-catalyzed oxazoline formation and intramolecular reductive amination by catalytic hydrogenation of an oxazoline is an effective method for the asymmetric synthesis of natural products possessing complex functionalized piperidine cores.

Original language	English
Pages (from-to)	87-93
Number of pages	7
Journal	Tetrahedron Asymmetry
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/S0957-4166(02)00794-2
Publication status	Published - 2003 Jan 6

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (01-PJ1-PG1-01CH13-0002).

All Science Journal Classification (ASJC) codes

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1016/S0957-4166(02)00794-2

Cite this

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title = "Stereoselective synthesis of (+)-spectaline",

abstract = "Our synthesis of (+)-spectaline revealed that the methodology involving diastereoselective palladium(0)-catalyzed oxazoline formation and intramolecular reductive amination by catalytic hydrogenation of an oxazoline is an effective method for the asymmetric synthesis of natural products possessing complex functionalized piperidine cores.",

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note = "Funding Information: This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (01-PJ1-PG1-01CH13-0002).",

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doi = "10.1016/S0957-4166(02)00794-2",

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T1 - Stereoselective synthesis of (+)-spectaline

AU - Lee, Yiu Suk

AU - Shin, Yong Ho

AU - Kim, Yong Hyun

AU - Lee, Kee Young

AU - Oh, Chang Young

AU - Pyun, Sung Jae

AU - Park, Hyun Ju

AU - Jeong, Jin Hyun

AU - Ham, Won Hun

N1 - Funding Information: This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (01-PJ1-PG1-01CH13-0002).

PY - 2003/1/6

Y1 - 2003/1/6

N2 - Our synthesis of (+)-spectaline revealed that the methodology involving diastereoselective palladium(0)-catalyzed oxazoline formation and intramolecular reductive amination by catalytic hydrogenation of an oxazoline is an effective method for the asymmetric synthesis of natural products possessing complex functionalized piperidine cores.

AB - Our synthesis of (+)-spectaline revealed that the methodology involving diastereoselective palladium(0)-catalyzed oxazoline formation and intramolecular reductive amination by catalytic hydrogenation of an oxazoline is an effective method for the asymmetric synthesis of natural products possessing complex functionalized piperidine cores.

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U2 - 10.1016/S0957-4166(02)00794-2

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SP - 87

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JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 1

ER -

Stereoselective synthesis of (+)-spectaline

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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