Standard guidelines for the chromosome-centric human proteome project

Young Ki Paik, Gilbert S. Omenn, Mathias Uhlen, Samir Hanash, György Marko-Varga, Ruedi Aebersold, Amos Bairoch, Tadashi Yamamoto, Pierre Legrain, Hyoung Joo Lee, Keun Na, Seul Ki Jeong, Fuchu He, Pierre Alain Binz, Toshihide Nishimura, Paul Keown, Mark S. Baker, Jong Shin Yoo, Jerome Garin, Alexander ArchakovJohn Bergeron, Ghasem Hosseini Salekdeh, William S. Hancock

Research output: Contribution to journalReview articlepeer-review

124 Citations (Scopus)


The objective of the international Chromosome-Centric Human Proteome Project (C-HPP) is to map and annotate all proteins encoded by the genes on each human chromosome. The C-HPP consortium was established to organize a collaborative network among the research teams responsible for protein mapping of individual chromosomes and to identify compelling biological and genetic mechanisms influencing colocated genes and their protein products. The C-HPP aims to foster the development of proteome analysis and integration of the findings from related molecular -omics technology platforms through collaborations among universities, industries, and private research groups. The C-HPP consortium leadership has elicited broad input for standard guidelines to manage these international efforts more efficiently by mobilizing existing resources and collaborative networks. The C-HPP guidelines set out the collaborative consensus of the C-HPP teams, introduce topics associated with experimental approaches, data production, quality control, treatment, and transparency of data, governance of the consortium, and collaborative benefits. A companion approach for the Biology and Disease-Driven HPP (B/D-HPP) component of the Human Proteome Project is currently being organized, building upon the Human Proteome Organization's organ-based and biofluid-based initiatives ( The common application of these guidelines in the participating laboratories is expected to facilitate the goal of a comprehensive analysis of the human proteome.

Original languageEnglish
Pages (from-to)2005-2013
Number of pages9
JournalJournal of Proteome Research
Issue number4
Publication statusPublished - 2012 Apr 6

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Chemistry(all)


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