Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging

Chulmin Joo, Taner Akkin, Barry Cense, Boris H. Park, Johannes F. De Boer

Research output: Contribution to journalArticlepeer-review

243 Citations (Scopus)


We describe a novel microscopy technique for quantitative phase-contrast imaging of a transparent specimen. The technique is based on depth-resolved phase information provided by common path spectral-domain optical coherence tomography and can measure minute phase variations caused by changes in refractive index and thickness inside the specimen. We demonstrate subnanometer level path-length sensitivity and present images obtained on reflection from a known phase object and human epithelial cheek cells.

Original languageEnglish
Pages (from-to)2131-2133
Number of pages3
JournalOptics Letters
Issue number16
Publication statusPublished - 2005 Aug 15

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics


Dive into the research topics of 'Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging'. Together they form a unique fingerprint.

Cite this