Spectral-domain optical coherence phase microscopy: A new optical imaging tool for quantitative biology

Suho Ryu, Chulmin Joo

Research output: Chapter in Book/Report/Conference proceedingChapter


Quantifying depth-resolved nanoscale dynamics in biological specimens (e.g., cells) provides a new dimension of study, which may serve as a means of phenotypically differentiating cellular responses to external stimuli and measuring molecular interactions in diverse platforms. Spectral-domain optical coherence phase microscopy (SD-OCPM) represents a novel optical microscopy technique, capable of measuring optical path-length changes inside the specimens with nanometer-level sensitivity. In this chapter, we describe operating principle and implementation of SD-OCPM. Theoretical discussion of SD-OCPM phase stability and spatial resolution will be presented, along with representative applications of SD-OCPM for quantitative biology. Future outlook and potential applications of SD-OCPM will also be discussed.

Original languageEnglish
Title of host publicationHandbook of Photonics for Biomedical Engineering
PublisherSpringer Netherlands
Number of pages26
ISBN (Electronic)9789400750524
ISBN (Print)9789400750517
Publication statusPublished - 2017 Jan 1

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media Dordrecht 2017.

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Physics and Astronomy(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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