Species distribution and macrolide susceptibility of mycobacterium fortuitum complex clinical isolates

Su Young Kim; Seong Mi Moon; Byung Woo Jhun; O. Jung Kwon; Hee Jae Huh; Nam Yong Lee; Seung Heon Lee; Sung Jae Shin; Shannon H. Kasperbauer; Gwen A. Huitt; Charles L. Daley; Won Jung Koh

doi:10.1128/AAC.02331-18

Species distribution and macrolide susceptibility of mycobacterium fortuitum complex clinical isolates

Su Young Kim, Seong Mi Moon, Byung Woo Jhun, O. Jung Kwon, Hee Jae Huh, Nam Yong Lee, Seung Heon Lee, Sung Jae Shin, Shannon H. Kasperbauer, Gwen A. Huitt, Charles L. Daley, Won Jung Koh

Department of Microbiology

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The understanding of species distribution and inducible macrolide resistance in the Mycobacterium fortuitum complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were M. fortuitum, followed by M. peregrinum, M. porcinum, M. septicum, and M. conceptionense. Most M. fortuitum, M. porcinum, and M. septicum isolates were inducibly resistant to clarithromycin, whereas two-thirds of the M. peregrinum isolates were clarithromycin susceptible. Clarithromycin-resistant M. fortuitum isolates exhibited common mutations of erm(39), potentially involved in clarithromycin resistance.

Original language	English
Article number	e02331-18
Journal	Antimicrobial agents and chemotherapy
Volume	63
Issue number	6
DOIs	https://doi.org/10.1128/AAC.02331-18
Publication status	Published - 2019 Jun

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) funded by the South Korea government (MSIT) (NRF-2018R1A2A1A05018309).

Publisher Copyright:
© 2019 American Society for Microbiology. All Rights Reserved.

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.02331-18

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Kim, S. Y., Moon, S. M., Jhun, B. W., Jung Kwon, O., Huh, H. J., Lee, N. Y., Lee, S. H., Shin, S. J., Kasperbauer, S. H., Huitt, G. A., Daley, C. L., & Koh, W. J. (2019). Species distribution and macrolide susceptibility of mycobacterium fortuitum complex clinical isolates. Antimicrobial agents and chemotherapy, 63(6), [e02331-18]. https://doi.org/10.1128/AAC.02331-18

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abstract = "The understanding of species distribution and inducible macrolide resistance in the Mycobacterium fortuitum complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were M. fortuitum, followed by M. peregrinum, M. porcinum, M. septicum, and M. conceptionense. Most M. fortuitum, M. porcinum, and M. septicum isolates were inducibly resistant to clarithromycin, whereas two-thirds of the M. peregrinum isolates were clarithromycin susceptible. Clarithromycin-resistant M. fortuitum isolates exhibited common mutations of erm(39), potentially involved in clarithromycin resistance.",

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doi = "10.1128/AAC.02331-18",

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AU - Shin, Sung Jae

AU - Kasperbauer, Shannon H.

AU - Huitt, Gwen A.

AU - Daley, Charles L.

AU - Koh, Won Jung

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) funded by the South Korea government (MSIT) (NRF-2018R1A2A1A05018309). Publisher Copyright: © 2019 American Society for Microbiology. All Rights Reserved.

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N2 - The understanding of species distribution and inducible macrolide resistance in the Mycobacterium fortuitum complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were M. fortuitum, followed by M. peregrinum, M. porcinum, M. septicum, and M. conceptionense. Most M. fortuitum, M. porcinum, and M. septicum isolates were inducibly resistant to clarithromycin, whereas two-thirds of the M. peregrinum isolates were clarithromycin susceptible. Clarithromycin-resistant M. fortuitum isolates exhibited common mutations of erm(39), potentially involved in clarithromycin resistance.

AB - The understanding of species distribution and inducible macrolide resistance in the Mycobacterium fortuitum complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were M. fortuitum, followed by M. peregrinum, M. porcinum, M. septicum, and M. conceptionense. Most M. fortuitum, M. porcinum, and M. septicum isolates were inducibly resistant to clarithromycin, whereas two-thirds of the M. peregrinum isolates were clarithromycin susceptible. Clarithromycin-resistant M. fortuitum isolates exhibited common mutations of erm(39), potentially involved in clarithromycin resistance.

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Species distribution and macrolide susceptibility of mycobacterium fortuitum complex clinical isolates

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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