The aim of this study was to determine the efficacy of crosslinked collagenated porcine bone (CPB) for the repair of surgically prepared one-wall intrabony defects in dogs. Buccolingually opened, one-wall, box-type periodontal defects (4 3 5 mm) were prepared bilaterally at the mesial side of the mandibular fourth premolars in beagle dogs (N55). Block-type CPB (4 3 5 3 5 mm) was placed on either the left or right side for the CPB site; the opposite site served as a sham-surgery control. Micro-computed tomographic and histological analyses were performed on block specimens obtained from the dogs after a 3-month healing period. There was less mean bone regeneration and cementum regeneration at the experimental sites than at the sham-surgery control sites. Most of the porcine bone particles were located under the floor of the defect and were sequestered from pristine bone. These findings show that CPB can be localized within the defect during the wound-healing period by a process of crosslinking; however, the application of CPB alone without a barrier membrane may not be effective in promoting periodontal regeneration in noncontained-type defects.
|Number of pages
|Journal of Biomedical Materials Research - Part B Applied Biomaterials
|Published - 2014 Oct 1
Bibliographical notePublisher Copyright:
© 2014 Wiley Periodicals, Inc.
All Science Journal Classification (ASJC) codes
- Biomedical Engineering