Solubility of progesterone, testosterone, and cholesterol in supercritical fluids

E. Kosal, C. H. Lee, G. D. Holder

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)


One potentially used application of supercritical fluid extraction (SCFE) is isolating and separating pharmaceuticals such as steroids. Experimental solubility data were obtained for testosterone, progesterone, and cholesterol in supercritical CO2 with and without N2O cosolvent over a pressure rage of 80 to 250 atm at 308.15-333.15 K. The addition of 10% (volume) N2O into CO2 increased the solubilities of these compounds by as much as one order of magnitude with larger effects occurring at lower pressures. Ternary systems (progesterone + testosterone + CO2, progesterone + testosterone + CO2, and testosterone + cholesterol + CO2) were also investigated. The experimental data were correlated by using a modified Peng-Robinson equation-of-state with density-dependent binary mixing rules, treating steroid vapor pressures in the form of the Clapeyron equation as adjustable correlating parameters.

Original languageEnglish
Pages (from-to)169-179
Number of pages11
JournalThe Journal of Supercritical Fluids
Issue number3
Publication statusPublished - 1992 Sept

All Science Journal Classification (ASJC) codes

  • General Chemical Engineering
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry


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