Smart, soft contact lens for wireless immunosensing of cortisol

Minjae Ku, Joohee Kim, Jong Eun Won, Wonkyu Kang, Young Geun Park, Jihun Park, Jae Hyun Lee, Jinwoo Cheon, Hyun Ho Lee, Jang Ung Park

Research output: Contribution to journalArticlepeer-review

148 Citations (Scopus)


Despite various approaches to immunoassay and chromatography for monitoring cortisol concentrations, conventional methods require bulky external equipment, which limits their use as mobile health care systems. Here, we describe a human pilot trial of a soft, smart contact lens for real-Time detection of the cortisol concentration in tears using a smartphone. A cortisol sensor formed using a graphene field-effect transistor can measure cortisol concentration with a detection limit of 10 pg/ml, which is low enough to detect the cortisol concentration in human tears. In addition, this soft contact lens only requires the integration of this cortisol sensor with transparent antennas and wireless communication circuits to make a smartphone the only device needed to operate the lens remotely without obstructing the wearer's view. Furthermore, in vivo tests using live rabbits and the human pilot experiment confirmed the good biocompatibility and reliability of this lens as a noninvasive, mobile health care solution.

Original languageEnglish
Article numbereabb2891
JournalScience Advances
Issue number28
Publication statusPublished - 2020 Jul 8

Bibliographical note

Publisher Copyright:
Copyright © 2020 The Authors, some rights reserved.

All Science Journal Classification (ASJC) codes

  • General


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